Orbital Development in Children with Retinoblastoma: An Imaging-Based Study.

IF 1.9 4区医学 Q2 OPHTHALMOLOGY Seminars in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-02-08 DOI:10.1080/08820538.2024.2312968

Shir Forer, Guy J Ben Simon, Gahl Greenberg, Lital Smadar, Amit Zabatani, Mattan Arazi, Ido Didi Fabian, Vicktoria Vishnevskia-Dai, Daphna Landau-Prat

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Abstract

Purpose: To examine whether children treated for Retinoblastoma (Rb) have impaired orbital development.

Methods: A retrospective case series was performed among children with Rb treated at a single medical center from 2004 to 2020. Orbital volumes and measurements were assessed by 3-dimensional image processing software. The main outcome measures were differences in orbital growth between Rb and non-Rb eyes assessed at last follow-up.

Results: Among 44 patients included (mean age 16.09 ± 18.01 months), a positive correlation between age and orbital volume was observed only in the uninvolved, healthy eyes (p = .03). In unilateral cases, orbital growth in the horizontal, vertical, and depth planes was smaller on the affected side compared to the healthy eyes (p < .05). Orbits that underwent enucleation showed decreased growth over time compared to those treated conservatively (p = .017).

Conclusions: Orbital growth rate is slower in the orbits of children treated for Rb compared to healthy orbits. Enucleation negatively affects orbital growth.

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视网膜母细胞瘤患儿的眼眶发育：基于成像的研究。

目的：研究视网膜母细胞瘤（Rb）患儿的眼眶发育是否受损：方法：对2004年至2020年在一家医疗中心接受治疗的视网膜母细胞瘤患儿进行回顾性病例系列研究。眼眶体积和测量值通过三维图像处理软件进行评估。主要结果指标是最后一次随访时评估的Rb眼与非Rb眼眼眶生长的差异：在纳入的 44 名患者中（平均年龄为 16.09 ± 18.01 个月），仅在未受累的健康眼中观察到年龄与眼眶体积呈正相关（p = .03）。在单侧病例中，与健康眼相比，患侧眼眶在水平面、垂直面和深度面上的生长较小（p p = .017）：结论：与健康眼眶相比，接受Rb治疗的儿童眼眶生长速度较慢。去核手术对眼眶生长有负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.