Clinical implications of C-reactive protein–albumin–lymphocyte (CALLY) index in patients with esophageal cancer

IF 2.3 4区医学 Q3 ONCOLOGY Surgical Oncology-Oxford Pub Date : 2024-02-05 DOI:10.1016/j.suronc.2024.102044

Ruiya Ma , Yoshinaga Okugawa , Tadanobu Shimura , Shinji Yamashita , Yuhki Sato , Chengzeng Yin , Ryo Uratani , Takahito Kitajima , Hiroki Imaoka , Mikio Kawamura , Yuhki Morimoto , Yoshiki Okita , Shigeyuki Yoshiyama , Masaki Ohi , Yuji Toiyama

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Abstract

Purpose

The C-reactive protein–albumin–lymphocyte (CALLY) index is a novel inflammatory nutritional biomarker. This study aimed to investigate the potential clinical significance and oncological prognostic role of the preoperative CALLY index in patients with esophageal cancer.

Methods

We analyzed the preoperative CALLY index in 146 patients with esophageal cancer. The CALLY index and clinicopathological variables were analyzed by the Mann–Whitney U test, and associations between the CALLY index and survival outcomes were analyzed by Kaplan–Meier analysis and log-rank tests. Univariate and multivariate analyses of prognostic variables were conducted using Cox proportional hazards regression.

Results

A lower preoperative CALLY index was significantly correlated with patient age, advanced T stage, presence of lymph node metastasis, neoadjuvant therapy, lymphatic invasion, and advanced stage classification. The preoperative CALLY index decreased significantly in a stage-dependent manner. Patients with esophageal cancer with a low CALLY index had poorer overall survival, disease-free survival than those with a high CALLY index. Multivariate analysis showed that a low CALLY index was an independent prognostic factor for overall survival, disease-free survival and an independent predictor of postoperative surgical site infection.

Conclusions

Preoperative CALLY index is a useful marker to guide the perioperative and postoperative management of patients with esophageal cancer.

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食管癌患者的 C 反应蛋白-白蛋白-淋巴细胞（CALLY）指数的临床意义

目的 C反应蛋白-白蛋白-淋巴细胞（CALLY）指数是一种新型炎症营养生物标志物。本研究旨在探讨食管癌患者术前 CALLY 指数的潜在临床意义和肿瘤预后作用。采用 Mann-Whitney U 检验分析 CALLY 指数和临床病理变量，采用 Kaplan-Meier 分析和对数秩检验分析 CALLY 指数和生存结果之间的关系。结果较低的术前CALLY指数与患者年龄、T期晚期、淋巴结转移、新辅助治疗、淋巴侵犯和晚期分期显著相关。术前CALLY指数的下降与分期有关。CALLY指数低的食管癌患者的总生存期和无病生存期均低于CALLY指数高的患者。多变量分析显示，低 CALLY 指数是总生存率和无病生存率的独立预后因素，也是术后手术部位感染的独立预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.