Prevention of epileptogenesis - are we there yet?

IF 4.1 2区医学 Q1 CLINICAL NEUROLOGY Current Opinion in Neurology Pub Date : 2024-02-13 DOI:10.1097/WCO.0000000000001256

Matthias Koepp, Eugen Trinka, Wolfgang Löscher, Pavel Klein

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Abstract

Purpose of review: To review recent progress in preventing epileptogenesis in patients with epilepsy.

Recent findings: The recent success of epilepsy prevention and disease modification in tuberous sclerosis using simple EEG biomarkers to guide treatment initiation, and the identification of biomarkers to enrich the targeted patient population has made clinical trials of epilepsy prevention after acquired central nervous system (CNS) insults such as traumatic brain injury, stroke or infection both feasible and timely. Two such trials are currently on-going to prevent poststroke epilepsy.

Summary: No disease-modifying or preventive treatments exist for epilepsy, and their development remains a major unmet need.. We have entered though the era of change in the treatment of epilepsy from symptomatic only to disease prevention. In this review, we summarize developments and review opportunities, challenges, and potential solutions to develop preventive treatment for acquired epilepsies in humans. The 'Holy Grail' of epilepsy is within our reach.

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预防癫痫发生--我们做到了吗？

综述目的：回顾预防癫痫患者癫痫发生的最新进展：最近在结节性硬化症中使用简单的脑电图生物标志物指导治疗的癫痫预防和疾病改变方面取得了成功，并确定了生物标志物以丰富目标患者人群，这使得在获得性中枢神经系统（CNS）损伤（如脑外伤、中风或感染）后进行癫痫预防的临床试验既可行又及时。目前正在进行两项这样的试验，以预防中风后癫痫。我们已经进入了癫痫治疗从仅对症治疗向疾病预防转变的时代。在这篇综述中，我们总结了人类在获得性癫痫预防性治疗方面的发展，并回顾了机遇、挑战和潜在的解决方案。癫痫的 "圣杯 "近在咫尺。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurology 医学-临床神经学

CiteScore

8.60

自引率

0.00%

发文量

174

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Neurology is a highly regarded journal offering insightful editorials and on-the-mark invited reviews; covering key subjects such as cerebrovascular disease, developmental disorders, neuroimaging and demyelinating diseases. Published bimonthly, each issue of Current Opinion in Neurology introduces world renowned guest editors and internationally recognized academics within the neurology field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature.