Influences of Genetic and Environmental Factors on Chronic Migraine: A Narrative Review.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY Current Pain and Headache Reports Pub Date : 2024-04-01 Epub Date: 2024-02-16 DOI:10.1007/s11916-024-01228-4

Po-Kuan Yeh, Yu-Chin An, Kuo-Sheng Hung, Fu-Chi Yang

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Abstract

Purpose of review: In this narrative review, we aim to summarize recent insights into the complex interplay between environmental and genetic factors affecting the etiology, development, and progression of chronic migraine (CM).

Recent findings: Environmental factors such as stress, sleep dysfunction, fasting, hormonal changes, weather patterns, dietary compounds, and sensory stimuli are critical triggers that can contribute to the evolution of episodic migraine into CM. These triggers are particularly influential in genetically predisposed individuals. Concurrently, genome-wide association studies (GWAS) have revealed over 100 genetic loci linked to migraine, emphasizing a significant genetic basis for migraine susceptibility. In CM, environmental and genetic factors are of equal importance and contribute to the pathophysiology of the condition. Understanding the bidirectional interactions between these elements is crucial for advancing therapeutic approaches and preventive strategies. This balanced perspective encourages continued research into the complex gene-environment nexus to improve our understanding and management of CM.

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遗传和环境因素对慢性偏头痛的影响：叙述性综述。

综述的目的：在这篇叙述性综述中，我们旨在总结最近对影响慢性偏头痛（CM）的病因、发展和进展的环境和遗传因素之间复杂的相互作用的认识：最近的发现：压力、睡眠功能障碍、禁食、荷尔蒙变化、天气模式、饮食化合物和感官刺激等环境因素是导致偶发性偏头痛演变为慢性偏头痛的关键诱因。这些诱因对遗传易感人群的影响尤为明显。同时，全基因组关联研究（GWAS）发现了 100 多个与偏头痛相关的基因位点，强调了偏头痛易感性的重要遗传基础。在中医中，环境因素和遗传因素同等重要，共同作用于偏头痛的病理生理学。了解这些因素之间的双向相互作用对于推进治疗方法和预防策略至关重要。这种平衡的观点鼓励人们继续研究基因与环境之间的复杂关系，以提高我们对中医的认识和管理水平。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.