Acute Kidney Injury After Thyroid Hormone Withdrawal in an Adolescent with Papillary Thyroid Carcinoma.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Journal of Clinical Research in Pediatric Endocrinology Pub Date : 2024-02-20 DOI:10.4274/jcrpe.galenos.2024.2023-11-10

Yavuz Özer, Rüveyda Gülmez, Hande Turan, Gürkan Tarçın, Dilek Bingöl Aydın, Olcay Evliyaoğlu, Oya Ercan

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Abstract

Objectives: We report a patient with papillary thyroid carcinoma (PTC) who developed acute kidney injury (AKI) and elevated creatine kinase (CK) after thyroid hormone withdrawal (THW) prior to radioiodine therapy.

Case presentation: A 12-year-old female patient who had undergone total thyroidectomy for PTC one year ago presented with leg pain for the past 2 days. Following THW 3 weeks ago, the case had received 70 mCI radioiodine treatment 6 days ago. Serum creatinine (1.53 mg/dL, normal range [NR]: 0.3-1.1), aspartate aminotransferase (102 IU/L, NR: 0-40) and CK (3451 IU/L, NR: 26-174) levels were elevated. Thyrotropin level was elevated (>100 µIU/ml, NR: 0.51-4.3), and free T4 level was decreased (0.05 ng/dL, NR: 0.98-1.63). Serum creatinine and CK levels decreased after intravenous hydration and levothyroxine treatment.

Conclusion: In PTC cases with thyroidectomy, kidney function and CK elevation should be assessed after THW and dehydration should be prevented.

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甲状腺乳头状癌青少年停用甲状腺激素后的急性肾损伤

目的：我们报告了一名甲状腺乳头状癌（PTC）患者在接受放射性碘治疗前停用甲状腺激素（THW）后出现急性肾损伤（AKI）和肌酸激酶（CK）升高的病例：一位12岁的女性患者一年前因PTC接受了甲状腺全切除术，在过去的两天里出现腿部疼痛。继 3 周前的 THW 之后，患者于 6 天前接受了 70 mCI 的放射性碘治疗。血清肌酐（1.53 mg/dL，正常范围 [NR]：0.3-1.1）、天冬氨酸氨基转移酶（102 IU/L，正常范围：0-40）和肌酸激酶（3451 IU/L，正常范围：26-174）水平升高。促甲状腺激素水平升高（>100 µIU/ml，NR：0.51-4.3），游离 T4 水平降低（0.05 ng/dL，NR：0.98-1.63）。静脉补液和左旋甲状腺素治疗后，血清肌酐和CK水平下降：结论：对于甲状腺切除术后的 PTC 病例，应在 THW 术后评估肾功能和 CK 升高情况，并防止脱水。

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来源期刊

Journal of Clinical Research in Pediatric Endocrinology ENDOCRINOLOGY & METABOLISM-PEDIATRICS

CiteScore

3.60

自引率

5.30%

发文量

审稿时长

20 weeks

期刊介绍： The Journal of Clinical Research in Pediatric Endocrinology (JCRPE) publishes original research articles, reviews, short communications, letters, case reports and other special features related to the field of pediatric endocrinology. JCRPE is published in English by the Turkish Pediatric Endocrinology and Diabetes Society quarterly (March, June, September, December). The target audience is physicians, researchers and other healthcare professionals in all areas of pediatric endocrinology.