Infrared-Driven Rapid Quantification of Magnetophoretically Trapped Drug

Abstract

This work presents a rapid quantification approach for on-chip, trapped magnetic nanoparticle drug conjugate (MD) and tests its in-vitro efficacy using an integrated piezoelectric/ferromagnetic bilayer structure-based magnetoelectric sensor coupled magnetic microfluidic device. The MD trapping is accomplished using triangular-shaped, patterned permanent magnet integrated using elastomer-free, pure NdFeB micro-powder that generates magnetic forces up to 0.2 pN on MDs. This trapped drug is flushed in a local concentration at the outlet well of the microfluidic device, where the magnetoelectric sensor is placed. The concentration and position of the trapped MD varies with the change in flow rate from 0.01- $0.1 ~\mu \text{l}$ /min. Upon exposure to IR (Infrared) irradiation pulses, the sensor detects 0.33-0.21 nA current for 0- $500 ~\mu \text{g}$ /ml concentration due to the pyroelectric effect and exhibits remarkable sensitivity (0.33 nA.ml/ $\mu \text{g}$ ) and response time ( $ < 2\text{s}$ ). [2023-0218]