Neural Oscillations and Functional Significances for Prioritizing Dual-Task Walking in Parkinson’s Disease

IF 4 3区医学 Q2 NEUROSCIENCES Journal of Parkinson's disease Pub Date : 2024-03-05 DOI:10.3233/jpd-230245

Cheng-Ya Huang, Yu-An Chen, Ruey-Meei Wu, Ing-Shiou Hwang

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Abstract

Background:

Task prioritization involves allocating brain resources in a dual-task scenario, but the mechanistic details of how prioritization strategies affect dual-task walking performance for Parkinson’s disease (PD) are little understood.

Objective:

We investigated the performance benefits and corresponding neural signatures for people with PD during dual-task walking, using gait-prioritization (GP) and manual-prioritization (MP) strategies.

Methods:

Participants (N = 34) were asked to hold two inter-locking rings while walking and to prioritize either taking big steps (GP strategy) or separating the two rings (MP strategy). Gait parameters and ring-touch time were measured, and scalp electroencephalograph was performed.

Results:

Compared with the MP strategy, the GP strategy yielded faster walking speed and longer step length, whereas ring-touch time did not significantly differ between the two strategies. The MP strategy led to higher alpha (8–12 Hz) power in the posterior cortex and beta (13–35 Hz) power in the left frontal-temporal area, but the GP strategy was associated with stronger network connectivity in the beta band. Changes in walking speed and step length because of prioritization negatively correlated with changes in alpha power. Prioritization-related changes in ring-touch time correlated negatively with changes in beta power but positively with changes in beta network connectivity.

Conclusions:

A GP strategy in dual-task walking for PD can enhance walking speed and step length without compromising performance in a secondary manual task. This strategy augments attentional focus and facilitates compensatory reinforcement of inter-regional information exchange.

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帕金森病患者优先考虑双任务行走的神经振荡和功能意义

摘要背景：任务优先化涉及在双任务场景中分配大脑资源，但人们对优先化策略如何影响帕金森病（PD）患者双任务步行表现的机制细节知之甚少。目的：我们研究了帕金森病患者在使用步态优先（GP）和手动优先（MP）策略进行双任务行走时的表现优势和相应的神经特征。方法：参与者（N = 34）被要求在行走时手持两个相互锁定的环，并优先迈出大步（GP策略）或分开两个环（MP策略）。结果：与 MP 策略相比，GP 策略的步行速度更快，步长更长，而触环时间在两种策略之间没有显著差异。MP策略在后部皮层产生更高的α（8-12赫兹）功率，在左额颞区产生更高的β（13-35赫兹）功率，但GP策略与β波段更强的网络连接有关。优先排序导致的步行速度和步长变化与阿尔法功率的变化呈负相关。结论：针对帕金森病的双任务步行中的 GP 策略可以提高步行速度和步长，同时不影响次要手动任务的表现。这种策略能增强注意力集中，促进区域间信息交流的补偿性强化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.