Application of RNA-based therapeutics in glioma: A review.

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2023-12-29 DOI:10.1016/bs.pmbts.2023.12.001

Mehdi Sanati, Amir R Afshari, Seyed Sajad Ahmadi, Tannaz Jamialahmadi, Amirhossein Sahebkar

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Abstract

Despite the extensive advancements made in the field of cancer therapy, the outlook of individuals suffering from glioblastoma multiforme remains highly detrimental. The absence of specific treatments for cancerous cells significantly hinders the effectiveness of conventional anticancer techniques. Multiple research studies have demonstrated that the suppression of specific genes or the augmentation of therapeutic proteins through RNA-based therapeutics may represent a valuable approach when combined with chemotherapy or immunotherapy. In recent years, there has been a significant increase in the application of RNA therapeutics in conjunction with chemotherapy and immunotherapy. This emerging field has become a prominent area of research for advancing various types of cancer treatments. The present investigation provides an in-depth overview of the classification and application of RNA therapy, focusing on the mechanisms of RNA antitumor treatment and the current status of clinical studies on RNA drugs.

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基于 RNA 的疗法在胶质瘤中的应用：综述。

尽管癌症治疗领域取得了长足的进步，但多形性胶质母细胞瘤患者的前景依然十分暗淡。由于缺乏针对癌细胞的特异性疗法，传统抗癌技术的效果大打折扣。多项研究表明，通过基于 RNA 的疗法抑制特定基因或增强治疗蛋白，与化疗或免疫疗法相结合，可能是一种有价值的方法。近年来，结合化疗和免疫疗法应用 RNA 疗法的情况显著增加。这一新兴领域已成为推进各类癌症治疗的一个突出研究领域。本研究深入概述了 RNA 疗法的分类和应用，重点介绍了 RNA 抗肿瘤治疗的机制以及 RNA 药物的临床研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.

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