Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-07-01 Epub Date: 2024-03-08 DOI:10.1016/j.tem.2024.02.011
Ifene David Festus, Jeri Spilberg, Martin E Young, Sean Cain, Sepideh Khoshnevis, Michael H Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A Martino
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Abstract

Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.

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开辟昼夜节律医学的新领域,促进心血管健康的慢性疗法。
心血管疾病(CVD)是全球关注的健康问题。昼夜节律医学可根据人体的日常节律及其潜在的细胞昼夜节律机制调整治疗方法,从而改善心血管疾病的治疗。基于时间的疗法(或称慢性疗法)在临床心脏病学中显示出特别的前景。这些疗法认识到人体节律周期的深远影响,优化了治疗计划,以获得更好的疗效,同时减少副作用。在这篇综述中,我们将重点关注三个有可能提高心血管治疗效果的时间疗法领域(用药、光照和用餐时间)。我们还重点介绍了在休息、肠道微生物组、高血压的新型时间疗法、疼痛治疗以及针对昼夜节律机制的小分子药物等新领域的开拓性研究。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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