Total lesion glycolysis by 18F-fluorodeoxyglucose positron emission tomography predicts tumor aggressiveness in patients with extrahepatic bile duct carcinoma

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-03-11 DOI:10.1002/jhbp.1421

Ryosuke Fukushima, Norifumi Harimoto, Shunsuke Kawai, Norihiro Ishii, Mariko Tsukagoshi, Takamichi Igarashi, Kenichiro Araki, Hiroyasu Tomonaga, Tetsuya Higuchi, Ken Shirabe

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Abstract

Background

¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG-PET/CT) parameters are prognostic factors in multiple malignancies. However, the prognostic value in bile duct carcinoma is unclear. We evaluated the impact of metabolic parameters of ¹⁸F-FDG-PET/CT in resectable extrahepatic bile duct carcinoma.

Methods

We retrospectively reviewed the records of 100 patients with extrahepatic bile duct carcinoma who had undergone ¹⁸F-FDG-PET/CT and subsequent surgical resection between January 2017 and January 2023. We calculated maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) and investigated their prognostic significance.

Results

The optimal cutoff values of SUVmax, MTV, and TLG for predicting overall survival (OS) after surgery were 3.88, 3.55 and 7.55, respectively. In multivariate analysis, each metabolic parameter influenced both OS and recurrence-free survival (RFS). TLG showed the lowest Akaike information criteria statistic value, indicating that it had the best ability to predict OS and RFS. High TLG was significantly associated with the number of lymph node metastases and poorly differentiated type. Patients with high TLG showed poorer RFS and OS, which were significantly worse than in those with low TLG.

Conclusions

Tumor TLG predicted tumor malignancy potential and could be a useful prognostic predictor for extrahepatic bile duct carcinoma.

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18 F-氟脱氧葡萄糖正电子发射断层扫描显示的病变总糖酵解可预测肝外胆管癌患者的肿瘤侵袭性。

背景：18 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18 F-FDG-PET/CT）参数是多种恶性肿瘤的预后因素。然而，胆管癌的预后价值尚不明确。我们评估了18 F-FDG-PET/CT代谢参数对可切除肝外胆管癌的影响：我们回顾性研究了 100 例肝外胆管癌患者的病历，这些患者在 2017 年 1 月至 2023 年 1 月期间接受了 18 F-FDG-PET/CT，随后进行了手术切除。我们计算了最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）和总病变糖酵解（TLG），并研究了它们的预后意义：预测术后总生存期（OS）的最佳SUVmax、MTV和TLG临界值分别为3.88、3.55和7.55。在多变量分析中，每个代谢参数都会影响OS和无复发生存率（RFS）。TLG的Akaike信息标准统计值最低，表明其预测OS和RFS的能力最强。高TLG与淋巴结转移数量和分化不良类型明显相关。高TLG患者的RFS和OS较差，明显低于低TLG患者：肿瘤TLG可预测肿瘤的恶性潜能，是肝外胆管癌预后的有效预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY

自引率

10.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.