Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Australian Endodontic Journal Pub Date : 2024-03-10 DOI:10.1111/aej.12835

Katherine Azevedo Batistela Rodrigues Thuller DDS, MSc, Lívia Azeredo Alves Antunes DDS, MSc, PhD, Prescila Mota de Oliveira Kublitski DDS, MSc, PhD, João Armando Brancher DDS, MSc, PhD, Flares Baratto-Filho DDS, MSc, PhD, Erika Calvano Küchler DDS, MSc, PhD, Alice Corrêa Silva-Sousa DDS, MSc, Manoel Damião Sousa-Neto DDS, MSc, PhD, Marilisa Carneiro Leão Gabardo DDS, MSc, PhD, Leonardo Santos Antunes DDS, MSc, PhD

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Abstract

This study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 and rs3934908) and RUNX2 (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real-time polymerase chain reaction. Statistical analyses, including Chi-Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the SMAD6 gene showed an association with genotype distribution in the recessive model (p = 0.049). The T–T haplotype in the SMAD6 gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (p = 0.029). No associations were found between PS risk and genetic polymorphisms in BMP2, BMP4 and RUNX2. Polymorphisms in the SMAD6 gene were associated with PS.

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BMP2、BMP4、SMAD6 和 RUNX2 基因多态性与牙髓结石的研究。

本研究旨在评估 BMP2（rs1005464 和 rs235768）、BMP4（rs17563）、SMAD6（rs2119261 和 rs3934908）和 RUNX2（rs59983488 和 rs1200425）的基因多态性与牙髓结石（PS）之间的关系。研究共纳入了 117 名参与者，其中 63 人患有牙髓结石，54 人没有牙髓结石。研究人员使用了数字X光片和一份人口统计学/临床问卷。通过实时聚合酶链反应对唾液细胞中的基因组 DNA 进行基因分型。统计分析包括Chi-Square、费雪精确检验、泊松回归和降维。在隐性模型中，SMAD6 基因中的 rs2119261 多态性与基因型分布有关（p = 0.049）。SMAD6 基因中的 T-T 单倍型（rs2119261 和 rs3934908）在对照组中更为普遍，且与 PS 有显著关联（p = 0.029）。未发现 PS 风险与 BMP2、BMP4 和 RUNX2 基因多态性之间存在关联。SMAD6 基因的多态性与 PS 相关。

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.