Epidemiological, clinical, diagnostic, and therapeutic features of histoplasmosis: A systematic review

IF 2.2 4区医学 Q3 MYCOLOGY Journal de mycologie medicale Pub Date : 2024-03-11 DOI:10.1016/j.mycmed.2024.101474

Adama Zida , Thierry K Guiguemdé , Marcel P Sawadogo , Chanolle Tchekounou , Ibrahim Sangaré , Sanata Bamba

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Abstract

Histoplasmosis is a mycosis due to a dimorphic fungus Histoplasma capsulatum. This study aimed at providing an overview of histoplasmosis epidemiological, clinical, diagnostic, and therapeutic aspects from the last 30 years.

This review was carried out using a systematic literature search on histoplasmosis from 1992 to 2021. We describe the clinical features, diagnostic methods and treatment. Empirical searches were conducted via the databases PubMed, Google Scholar and Science Direct.

Between 1992 and 2021, 190 manuscripts were published and reported 212 cases of histoplasmosis. These publications included 115 and 97 cases of American and African histoplasmosis respectively. The number of publications increased over the last ten years with a maximum in 2020 (12.34 % of the cases reported). The disseminated forms of histoplasmosis were the most frequently reported cases as compared to the localized forms. This was the case with the American histoplasmosis (75.65 %) as well as with the African histoplasmosis (55.67 %). Itraconazole (31.17 %) and Amphotericin B (26.62 %) were the most used drugs in the management of these cases.

American histoplasmosis is distributed worldwide whereas African histoplasmosis is mainly present in intertropical Africa. There is a critical need for setting up a global surveillance system, towards a better understanding of the disease.

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组织胞浆菌病的流行病学、临床、诊断和治疗特征：系统综述

组织胞浆菌病是由一种二形真菌荚膜组织胞浆菌引起的真菌病。本研究旨在概述过去 30 年来组织胞浆菌病在流行病学、临床、诊断和治疗方面的情况。我们描述了组织胞浆菌病的临床特征、诊断方法和治疗方法。我们通过 PubMed、Google Scholar 和 Science Direct 数据库进行了经验性检索。1992 年至 2021 年间，共发表了 190 篇手稿，报告了 212 例组织胞浆菌病。1992年至2021年期间，共发表了190篇手稿，报告了212个组织胞浆菌病病例。在过去十年中，发表文章的数量有所增加，2020 年达到最高峰（占报告病例的 12.34%）。与局部型组织胞浆菌病相比，播散型组织胞浆菌病是最常报道的病例。美洲组织胞浆菌病（75.65%）和非洲组织胞浆菌病（55.67%）就是这种情况。伊曲康唑（31.17%）和两性霉素 B（26.62%）是治疗这些病例最常用的药物。为了更好地了解这种疾病，迫切需要建立一个全球监测系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal de mycologie medicale 医学-真菌学

CiteScore

5.10

自引率

2.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal de Mycologie Medicale / Journal of Medical Mycology (JMM) publishes in English works dealing with human and animal mycology. The subjects treated are focused in particular on clinical, diagnostic, epidemiological, immunological, medical, pathological, preventive or therapeutic aspects of mycoses. Also covered are basic aspects linked primarily with morphology (electronic and photonic microscopy), physiology, biochemistry, cellular and molecular biology, immunochemistry, genetics, taxonomy or phylogeny of pathogenic or opportunistic fungi and actinomycetes in humans or animals. Studies of natural products showing inhibitory activity against pathogenic fungi cannot be considered without chemical characterization and identification of the compounds responsible for the inhibitory activity. JMM publishes (guest) editorials, original articles, reviews (and minireviews), case reports, technical notes, letters to the editor and information. Only clinical cases with real originality (new species, new clinical present action, new geographical localization, etc.), and fully documented (identification methods, results, etc.), will be considered. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey platforms.