Effect of Pirdot Leaf Extract (Saurauia Vulcani Korth ) on SGPT and SGOT Value in Wistar Strain Rats Induced by Salmonella Typhimurium.

Medical archives (Sarajevo, Bosnia and Herzegovina) Pub Date : 2024-01-01 DOI:10.5455/medarh.2024.78.9-11

Haslinda Haslinda, Yunita Sari Pane

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Abstract

Background: Typhoid fever is an acute disease caused by Salmonella typhimurium that can invade the liver and cause symptoms of hepatomegaly,jaundice.Biochemically, these symptoms can be assessed by seeing the SGPT and SGOT levels increase. Pirdot Leaf is an herbal plant found in the Toba area of North Sumatra which has a lot of bioactive potential,namely flavonoids,steroids, saponins. Flavonoids are active substances that can overcome the inflammatory process, it is expected that the administration of Pirdot leaf extract can reduce levels of SGOT and SGPT in mice induced Salmonella Typhimurium.

Objective: The purpose of this study was to determine the effect of ethanol extract of pirdot leaves on SGPT and SGOT values in rat models induced by Salmonella typhimurium. Methods: This study used 32 samples divided into four groups namely: Normal group, Negative group, Positive group and Treatment group. Results: The results were obtained for normal control SGPT (27,85) negative control (37,80) positive control (27,30) and for Dick treatment (26,21). The results of the study for SGPT obtained normal control (73,18), negative control (120,23), positive control (92,89), and treatment control (78,68).

Conclusion: Giving ethanol extract of pirdot leaves effect on reducing SGPT and SGOT levels in wistar strain mice induced Salmonella typhimurium.

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Pirdot 叶提取物（Saurauia Vulcani Korth）对鼠伤寒沙门氏菌诱导的 Wistar 种大鼠 SGPT 和 SGOT 值的影响

背景：伤寒是由伤寒沙门氏菌（Salmonella typhimurium）引起的一种急性疾病，伤寒沙门氏菌可侵入肝脏，引起肝肿大、黄疸等症状。Pirdot Leaf 是一种草本植物，产于北苏门答腊的多巴地区，具有大量生物活性潜能，即黄酮类、类固醇和皂苷。黄酮类化合物是能克服炎症过程的活性物质，预计服用 Pirdot 叶提取物能降低小鼠诱导的鼠伤寒沙门氏菌的 SGOT 和 SGPT 水平：本研究旨在确定雀巢叶乙醇提取物对鼠伤寒沙门氏菌诱导的大鼠模型中 SGPT 和 SGOT 值的影响。研究方法本研究使用了 32 份样本，分为四组，即：正常组、阴性组、阳性组和阴性组：正常组、阴性组、阳性组和治疗组。结果：正常对照组正常对照组 SGPT（27,85）、阴性对照组（37,80）、阳性对照组（27,30）和迪克治疗组（26,21）的结果。对 SGPT 的研究结果为正常对照组（73,18）、阴性对照组（120,23）、阳性对照组（92,89）和治疗对照组（78,68）：给予雀巢叶乙醇提取物可降低由鼠伤寒沙门氏菌诱导的 Wistar 株小鼠的 SGPT 和 SGOT 水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Medical archives (Sarajevo, Bosnia and Herzegovina)

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