Targeted Agents in Esophagogastric Cancer Beyond Human Epidermal Growth Factor Receptor-2

IF 2.5 3区 医学 Q2 HEMATOLOGY Hematology-Oncology Clinics of North America Pub Date : 2024-03-13 DOI:10.1016/j.hoc.2024.02.006
Eric Mehlhaff MD , Devon Miller MD , Johnathan D. Ebben MD, PhD , Oleksii Dobrzhanskyi MD , Nataliya V. Uboha MD, PhD
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超越人类表皮生长因子受体-2 的食管胃癌靶向药物
胃食管癌是一种在解剖学和分子特征方面高度多样化的肿瘤,这使得药物开发具有挑战性。最近,人们在了解这些癌症的分子特征方面取得了进展,发现了一些新的生物标志物。目前正在进行的临床试验正在研究新的靶向药物,并取得了可喜的成果。CLDN18.2已成为一种生物标志物,具有相关靶向疗法的既定活性。其他靶向药物,如贝马单抗和 DKN-01 也在积极研究中。随着新药被纳入治疗方案,生物标志物重叠、肿瘤异质性和毒性管理等问题将需要得到解决。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Hematology/Oncology Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Under the direction of an experienced guest editor, each issue focuses on a single topic in hematology and oncology, including hemostasis and thrombosis, molecular and cellular basis of hematology, coagulation disorders, and cancers—bone, gastrointestinal, head and neck, lymphomas, neuroendocrine, breast, renal cell, melanoma, and more.
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Emergence of Circulating Tumor DNA as a Precision Biomarker in Lung Cancer Radiation Oncology and Beyond. Gene Signatures and Oncology Treatment Implications. Heavy Ion Particle Therapy in Modern Day Radiation Oncology. Patient-Reported Outcomes in Radiation Oncology. Contents
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