The role of cardiac microenvironment in cardiovascular diseases: implications for therapy

IF 4.3 3区生物学 Human Cell Pub Date : 2024-03-18 DOI:10.1007/s13577-024-01052-3

Jiayu Yao, Yuejun Chen, Yuqing Huang, Xiaoou Sun, Xingjuan Shi

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Abstract

Due to aging populations and changes in lifestyle, cardiovascular diseases including cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death worldwide. The heart is a complicated organ composed of multicellular types, including cardiomyocytes, fibroblasts, endothelial cells, vascular smooth muscle cells, and immune cells. Cellular specialization and complex interplay between different cell types are crucial for the cardiac tissue homeostasis and coordinated function of the heart. Mounting studies have demonstrated that dysfunctional cells and disordered cardiac microenvironment are closely associated with the pathogenesis of various cardiovascular diseases. In this paper, we discuss the composition and the homeostasis of cardiac tissues, and focus on the role of cardiac environment and underlying molecular mechanisms in various cardiovascular diseases. Besides, we elucidate the novel treatment for cardiovascular diseases, including stem cell therapy and targeted therapy. Clarification of these issues may provide novel insights into the prevention and potential targets for cardiovascular diseases.

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心脏微环境在心血管疾病中的作用：对治疗的影响

由于人口老龄化和生活方式的改变，包括心肌病、高血压和动脉粥样硬化在内的心血管疾病已成为全球死亡的主要原因。心脏是一个由心肌细胞、成纤维细胞、内皮细胞、血管平滑肌细胞和免疫细胞等多细胞类型组成的复杂器官。不同细胞类型之间的细胞特化和复杂的相互作用对心脏组织的平衡和协调功能至关重要。越来越多的研究表明，功能失调的细胞和紊乱的心脏微环境与各种心血管疾病的发病机制密切相关。本文讨论了心脏组织的组成和稳态，并重点探讨了心脏环境在各种心血管疾病中的作用及其潜在的分子机制。此外，我们还阐明了心血管疾病的新型治疗方法，包括干细胞治疗和靶向治疗。这些问题的澄清可为心血管疾病的预防和潜在靶点提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Cell 生物-细胞生物学

CiteScore

6.60

自引率

2.30%

发文量

176

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.