Cihan Kantar, Nimet Baltaş, Şengül Alpay Karaoğlu, Selami Şaşmaz
{"title":"Some Schiff Bases Containing Eugenol and Guaiacol: Comparison of Urease Inhibition and Anti-Helicobacter pylori Activities with Its Azo Analogs","authors":"Cihan Kantar, Nimet Baltaş, Şengül Alpay Karaoğlu, Selami Şaşmaz","doi":"10.1007/s11094-024-03074-5","DOIUrl":null,"url":null,"abstract":"<p>To improve and develop our monotherapeutic approach for <i>Helicobacter pylori</i> infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-<i>Helicobacter pylori</i> effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter <i>pylori</i> properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.</p>","PeriodicalId":19990,"journal":{"name":"Pharmaceutical Chemistry Journal","volume":"91 1","pages":""},"PeriodicalIF":0.8000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutical Chemistry Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11094-024-03074-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
To improve and develop our monotherapeutic approach for Helicobacter pylori infection, some Schiff base compounds containing eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition, and Anti-Helicobacter pylori effect were investigated and compared with azo analogs in the literature. All Schiff base compounds have been found to have both stronger urease enzyme inhibitory and more effective Anti-Helicobacter pylori properties than its azo analogs. In particular, the antimicrobial effect of Schiff bases containing eugenol increased dramatically when compared to their azo analogs.
期刊介绍：
Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including:
methods of synthesis;
results of pharmacological, toxicological, and biochemical studies;
investigation of structure - activity relationships in prediction of new compounds;
methods and technical facilities used; and
problems associated with the development of ecologically safe and economically feasible methods of industrial production.
In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world.
Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April.
All articles are peer-reviewed.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
