Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Aortic Regurgitation.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Current Cardiology Reports Pub Date : 2024-05-01 Epub Date: 2024-03-22 DOI:10.1007/s11886-024-02044-3

Mujtaba Saeed, Akila Bersali, Amr Darwish, Fatima Qamar, Dimitrios Maragiannis, Kinan Carlos El-Tallawi, Maan Malahfji, Dipan J Shah

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Abstract

Purpose of review: Cardiac magnetic resonance (CMR) is emerging as a valuable imaging modality for the assessment of aortic regurgitation (AR). In this review, we discuss the assessment of AR severity, left ventricular (LV) remodeling, and tissue characterization by CMR while highlighting the latest studies and addressing future research needs.

Recent findings: Recent studies have further established CMR-based thresholds of AR severity and LV remodeling that are associated with adverse clinical outcomes, and lower than current guideline criteria. In addition, tissue profiling with late gadolinium enhancement (LGE) and extracellular volume (ECV) quantification can reliably assess adverse myocardial tissue remodeling which is also associated with adverse outcomes. The strengths and reproducibility of CMR in evaluating ventricular volumes, tissue characteristics, and regurgitation severity position it as an excellent modality in evaluating and following AR patients. Advanced CMR techniques for the detection of tissue remodeling have shown significant potential and merit further investigation.

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用 CMR 评估主动脉瓣反流的反流严重程度、不良重塑和纤维化。

审查目的：心脏磁共振（CMR）正在成为评估主动脉瓣反流（AR）的一种重要成像方式。在这篇综述中，我们将讨论通过 CMR 评估 AR 的严重程度、左心室（LV）重塑和组织特征，同时重点介绍最新的研究并探讨未来的研究需求：最新研究结果：最新研究进一步确定了基于 CMR 的 AR 严重程度和左心室重塑阈值，这些阈值与不良临床预后相关，且低于现行指南标准。此外，通过晚期钆增强（LGE）和细胞外容积（ECV）量化进行组织分析，可以可靠地评估不良心肌组织重塑，这也与不良预后有关。CMR 在评估心室容积、组织特征和反流严重程度方面的优势和可重复性使其成为评估和随访 AR 患者的绝佳方式。用于检测组织重塑的先进 CMR 技术已显示出巨大的潜力，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.