Sarah Anne Wong, Victoria A Manon, Simon Young, Chi T Viet
{"title":"Innovations in Molecular Biomarkers and Biomaterial-Based Immunotherapies for Head & Neck Cancer.","authors":"Sarah Anne Wong, Victoria A Manon, Simon Young, Chi T Viet","doi":"10.1007/s40137-024-00386-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Oral squamous cell carcinoma (OSCC) survival rates have remained stagnant due to a lack of targeted therapies and diagnostic tools. Patient risk is currently determined solely through clinicopathologic features, primarily tumor staging, which lacks the necessary precision to stratify patients by risk and accurately dictate adjuvant treatment. Similarly, conventional OSCC therapies have well-established toxicities and limited efficacy.</p><p><strong>Recent findings: </strong>Recent studies show that patient risk can now be assessed using non-invasive techniques, at earlier time points, and with greater accuracy using molecular biomarker panels. Additionally, novel immunotherapies not only utilize the host's immune response to combat disease but also have the potential to form immunological memory to prevent future recurrence. Localized controlled-release formulas have further served to reduce toxicity and allow the de-escalation of other treatment modalities.</p><p><strong>Summary: </strong>We review the latest advances in head and neck cancer diagnosis and treatment, including novel molecular biomarkers and immunotherapies.</p>","PeriodicalId":44090,"journal":{"name":"Current Surgery Reports","volume":"12 4","pages":"45-51"},"PeriodicalIF":0.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954983/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Surgery Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40137-024-00386-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose of review: Oral squamous cell carcinoma (OSCC) survival rates have remained stagnant due to a lack of targeted therapies and diagnostic tools. Patient risk is currently determined solely through clinicopathologic features, primarily tumor staging, which lacks the necessary precision to stratify patients by risk and accurately dictate adjuvant treatment. Similarly, conventional OSCC therapies have well-established toxicities and limited efficacy.
Recent findings: Recent studies show that patient risk can now be assessed using non-invasive techniques, at earlier time points, and with greater accuracy using molecular biomarker panels. Additionally, novel immunotherapies not only utilize the host's immune response to combat disease but also have the potential to form immunological memory to prevent future recurrence. Localized controlled-release formulas have further served to reduce toxicity and allow the de-escalation of other treatment modalities.
Summary: We review the latest advances in head and neck cancer diagnosis and treatment, including novel molecular biomarkers and immunotherapies.
期刊介绍：
This journal aims to offer expert review articles on the most significant recent developments in the field of surgery. By providing clear, insightful, balanced contributions, the journal intends to serve those for whom the elucidation of novel surgical techniques and related technologies is essential. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include bariatric surgery; CT screening; endovascular treatment of complex vasculopathies; minimally invasive surgery; natural orifice surgery; and transplantation.
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