Effect of intravenous lipid therapy in critically ill pediatric patients with calcium channel blocker toxicity.

The Turkish journal of pediatrics Pub Date : 2024-01-01 DOI:10.24953/turkjped.2023.543

Sinan Yavuz, Ali Avcı, Rabia Gündoğan Serin, Mustafa Mesut Kaya, Dilfuza Ağalıoğlu

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Abstract

Background: Overdose with calcium-channel blockers (CCBs) still maintain their importance with a high lethality rate after exposure. We report the intravenous lipid emulsion therapy (ILE) therapy in our CCB overdose patients.

Methods: We retrospectively analyzed the records of 6 patients with CCB intoxication from Batman Training and Research Hospital PICU between March 2021 and September 2022. Patients aged 0-18 years who received ILE treatment for CCB poisoning were included.

Results: All six patients ingested CCB with the intention of committing suicide and were followed up in the pediatric intensive care unit (PICU). All patients received ILE therapy due to hemodynamic instability despite intravenous fluid boluses, calcium, glucagon, insulin-dextrose, and vasoactive agents. Vasoactive-Inotropic Score (VIS) decreased after ILE treatment. All patients were transferred from the PICU after recovery.

Conclusions: ILE therapy should be kept in mind as a salvage therapy in hemodynamically unstable CCB poisoning cases that do not respond to initial and advanced options.

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静脉注射脂质疗法对钙通道阻滞剂中毒的儿科重症患者的影响。

背景：钙通道阻滞剂（CCB）用药过量仍具有重要意义，暴露后致死率很高。我们报告了钙离子通道阻滞剂过量患者的静脉脂质乳剂疗法（ILE）：我们回顾性分析了 2021 年 3 月至 2022 年 9 月期间蝙蝠侠训练研究医院 PICU 的 6 例氯苯中毒患者的病历。方法：我们回顾分析了 2021 年 3 月至 2022 年 9 月期间蝙蝠侠培训研究医院 PICU 的 6 名氯苯中毒患者的病历，其中包括因氯苯中毒接受 ILE 治疗的 0-18 岁患者：结果：所有六名患者均以自杀为目的摄入氯苯，并在儿科重症监护室（PICU）接受随访。所有患者均因血流动力学不稳定而接受了 ILE 治疗，尽管静脉注射了液体、钙剂、胰高血糖素、胰岛素-葡萄糖和血管活性药物。ILE 治疗后，血管活性-肌张力评分（VIS）下降。所有患者在康复后都转出了重症监护病房：结论：ILE疗法作为一种挽救疗法，在血流动力学不稳定的氯苯中毒病例中应牢记这一点。

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The Turkish journal of pediatrics

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