B. Wang, X. Y. Ma, W. Yao, S. Y. Wu, Y. Zhang, W. Liu, E. J. Gao
{"title":"Binding Studies of Novel Manganese Complexes to DNA","authors":"B. Wang, X. Y. Ma, W. Yao, S. Y. Wu, Y. Zhang, W. Liu, E. J. Gao","doi":"10.1134/s0036023623603033","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.</p>","PeriodicalId":762,"journal":{"name":"Russian Journal of Inorganic Chemistry","volume":"16 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Inorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1134/s0036023623603033","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
A new Mn(II) complex was designed and synthesized in hydrothermal conditions using phenylmalonic acid and phosphine as raw materials. The effective characterization method was single-crystal X-ray diffraction. Besides, the interaction with FS-DNA (fish sperm DNA) and the DNA binding constants of the complex were determined by UV spectroscopy. The results showed that it was a significant apoptotic effect on cancer cells; therefore, the synthesized Mn(II) complex is important for the treatment of cancer.
期刊介绍:
Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.