G. Sujatha, Devi A. Mathunika, Josephine J. Lesy, P. Punitha, P. Ramanathan
{"title":"Efficient biological activity of acridine synthesised by using efficient nano catalyst","authors":"G. Sujatha, Devi A. Mathunika, Josephine J. Lesy, P. Punitha, P. Ramanathan","doi":"10.25303/283rjce056060","DOIUrl":null,"url":null,"abstract":"A simple and efficient protocol for 9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexa hydroacridine-1,8(2H,5H)-dione (MPTH) was synthesised by conventional method by using efficient nano catalyst. The crystallite sizes (L) and surface area (S) of TiO2 are 10.44 nm and 140.32 m2/g. MPTH displayed wide inhibitions on the KB cell appearance with IC50 values 25.06 μg. The IC50 values of the MPTH imply that methoxy substituted compound holds more inhibitory effect against the cancer cells.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research Journal of Chemistry and Environment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25303/283rjce056060","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Earth and Planetary Sciences","Score":null,"Total":0}
引用次数: 0
Abstract
A simple and efficient protocol for 9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexa hydroacridine-1,8(2H,5H)-dione (MPTH) was synthesised by conventional method by using efficient nano catalyst. The crystallite sizes (L) and surface area (S) of TiO2 are 10.44 nm and 140.32 m2/g. MPTH displayed wide inhibitions on the KB cell appearance with IC50 values 25.06 μg. The IC50 values of the MPTH imply that methoxy substituted compound holds more inhibitory effect against the cancer cells.
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