Minipuberty period of children with atopic dermatitis compared to healthy children

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.55730/1300-0144.5795

S. Koca, Hatice Eke Güngör, Murat Cansever

引用次数: 0

Abstract

) levels were found to be higher (p = 0.023, p < 0.001, p = 0.038, and p = 0.034, respectively). In boys with AD, the FT4 level was found to be lower (p = 0.023). Serum FT4 and TSH levels were within normal reference ranges in all comparisons. Conclusion: Especially in girls with AD, decreased estradiol and IGF-1 levels were observed compared to the controls during minipuberty. In the logistic regression model, decreased levels of serum estradiol, dehydroepiandrosterone sulfate, FT4, and IGF-1, and increased levels of IGFBP3 were associated with an increased likelihood of exhibiting atopic dermatitis.

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与健康儿童相比，特应性皮炎患儿的未成年期

)水平较高（分别为 p = 0.023、p < 0.001、p = 0.038 和 p = 0.034）。在患有AD的男孩中，FT4水平较低（p = 0.023）。在所有比较中，血清 FT4 和促甲状腺激素水平均在正常参考范围内。结论与对照组相比，患有 AD 的女孩在青春期的雌二醇和 IGF-1 水平下降。在逻辑回归模型中，血清雌二醇、硫酸脱氢表雄酮、FT4和IGF-1水平的降低以及IGFBP3水平的升高与特应性皮炎患病几率的增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.