International Expert-Based Consensus Definition, Staging Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Inter-Disciplinary Modified Delphi Study
The International ORAL Consortium, Amy C. Moreno, Erin E. Watson, Laia Humbert-Vidan, Douglas E. Peterson, Lisanne V van Dijk, Teresa Guerrero Urbano, Lisa Van den Bosch, Andrew J. Hope, Matthew S. Katz, Frank J.P. Hoebers, Ruth A. Aponte Wesson, James E. Bates, Paolo Bossi, Adeyinka F. Dayo, Mélanie Doré, Eduardo Rodrigues Fregnani, Thomas J. Galloway, Daphna Y. Gelblum, Issa A. Hanna, Christina E. Henson, Sudarat Kiat-amnuay, Anke Korfage, Nancy Y. Lee, Carol M. Lewis, Charlotte Duch Lynggaard, Antti A. Mäkitie, Marco Magalhaes, Yvonne M. Mowery, Carles Muñoz-Montplet, Jeffrey N. Myers, Ester Orlandi, Jaymit Patel, Jillian M. Rigert, Deborah Saunders, Jonathan D. Schoenfeld, Ugur Selek, Efsun Somay, Vinita Takiar, Juliette Thariat, Gerda M. Verduijn, Alessandro Villa, Nick West, Max J.H. Witjes, Alex Won, Mark E. Wong, Christopher M.K.L. Yao, Simon W. Young, Kamal Al-eryani, Carly E.A. Barbon, Doke J.M. Buurman, François J. Dieleman, Theresa M. Hofstede, Abdul Ahad Khan, Adegbenga O. Otun, John C. Robinson, Lauren Hum, Jorgen Johansen, Rajesh Lalla, Alexander Lin, Vinod Patel, Richard J. Shaw, Mark S. Chambers, Daniel Ma, Mabi Singh, Noam Yarom, Abdallah Sherif Radwan Mohamed, Katherine A. Hutcheson, Stephen Y. Lai, Clifton David Fuller
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Abstract
Purpose Osteoradionecrosis of the jaw (ORNJ) is a severe iatrogenic disease characterized by bone death after radiation therapy (RT) to the head and neck. With over 9 published definitions and at least 16 diagnostic/staging systems, the true incidence and severity of ORNJ are obscured by lack of a standard for disease definition and severity assessment, leading to inaccurate estimation of incidence, reporting ambiguity, and likely under-diagnosis worldwide. This study aimed to achieve consensus on an explicit definition and phenotype of ORNJ and related precursor states through data standardization to facilitate effective diagnosis, monitoring, and multidisciplinary management of ORNJ.
目的 下颌骨骨坏死（Osteoradionecrosis of the jaw，ORNJ）是一种严重的先天性疾病，其特点是头颈部接受放射治疗（RT）后出现骨坏死。目前已公布的ORNJ定义有9种之多，诊断/分期系统至少有16种，但由于缺乏疾病定义和严重程度评估的标准，ORNJ的真实发病率和严重程度被掩盖了，导致全球范围内对发病率的估计不准确、报告不明确，而且很可能诊断不足。本研究旨在通过数据标准化，就 ORNJ 及相关前兆状态的明确定义和表型达成共识，以促进 ORNJ 的有效诊断、监测和多学科管理。
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