Chemical Composition and Antioxidant Activity of Petroleum Ether Extract from Kaempferia galanga L.

IF 0.8 4区 医学 Q4 CHEMISTRY, MEDICINAL Pharmaceutical Chemistry Journal Pub Date : 2024-04-17 DOI:10.1007/s11094-024-03101-5
Zhaobao Xiang, Xueli Ping, Pengfei Chen, Linfeng You, Bin Zhou
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Abstract

Kaempferia galanga L. (KGL) from Hainan, China was extracted by ultrasonic-assisted extraction with 90% ethanol solution, and then extracted with petroleum ether after the ethanol extract was recovered to be alcohol free. The antioxidant activity of the petroleum ether fraction of KGL was first tested using the ABTS method. GC-MS was used to analyze the chemical constituents of the petroleum ether fraction. The scavenging effect on ABTS free radicals of the petroleum ether fraction was weak, indicating that the antioxidant activity of the petroleum ether fraction was moderate. A total of 25 chemical components were identified by GC-MS analysis. The main components with higher content were 2,6,11-trimethyl dodecane, ethyl p-methoxy cinnamate, and ethyl cinnamate, which accounted for 81.64%. Furthermore, 11 kinds of constituents of the petroleum ether extract were obtained from KGL for the first time. This experiment clarifies firstly the main chemical composition of petroleum ether fraction from KGL, which provides some scientific basis for the further exploration and use of petroleum ether fraction from KGL and the comparative analysis of the chemical composition of KGL in different regions.

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山奈石油醚提取物的化学成分和抗氧化活性
用 90% 的乙醇溶液超声辅助提取中国海南的山奈(KGL),乙醇提取液回收至无醇后再用石油醚提取。首先用 ABTS 法检测了 KGL 石油醚馏分的抗氧化活性。采用 GC-MS 分析石油醚馏分的化学成分。石油醚馏分对 ABTS 自由基的清除作用较弱,表明石油醚馏分的抗氧化活性适中。通过气相色谱-质谱分析,共鉴定出 25 种化学成分。含量较高的主要成分是 2,6,11-三甲基十二烷、对甲氧基肉桂酸乙酯和肉桂酸乙酯,占 81.64%。此外,还首次从 KGL 中获得了 11 种石油醚提取物成分。该实验首次明确了KGL石油醚馏分的主要化学成分,为KGL石油醚馏分的进一步开发利用和不同地区KGL石油醚馏分化学成分的对比分析提供了一定的科学依据。
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来源期刊
Pharmaceutical Chemistry Journal
Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY
CiteScore
1.30
自引率
22.20%
发文量
226
审稿时长
3-8 weeks
期刊介绍: Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.
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