HHV-8 Linked to Kaposi's Sarcoma and Castleman's Disease in HIV-1-infected patient: Case Report and Review of the Literature

A. Zaghdoudi, Hajer Harrabi, Hanene Tiouiri Benaissa
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Abstract

Kaposi’s sarcoma (KS) and multicentric Castleman's disease (MCD) are both linked to human herpesvirus-8 (HHV-8) infection which most commonly affects people living with human immunodeficiency virus (HIV).  Herein, we describe the case of a 57-year-old patient who has been admitted for fever, night sweats, weight loss, and diffuse lymphadenopathy with abdominal pain. HIV status was confirmed by a positive Western blot test. His initial CD4 cell count was equal to 270 cells/µL. A histological study of a peripheral lymph node concluded that KS is associated with MCD. These two conditions found in the same patient highlight the malignant potential of HHV-8, particularly in the case of HIV-induced immunodeficiency.  
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HHV-8 与 HIV-1 感染者的卡波西肉瘤和 Castleman 病有关:病例报告与文献综述
卡波西肉瘤(KS)和多中心卡斯特曼病(MCD)都与人类疱疹病毒-8(HHV-8)感染有关,而人类疱疹病毒-8感染最常见于人类免疫缺陷病毒(HIV)感染者。 在此,我们描述了一例因发热、盗汗、体重减轻、弥漫性淋巴结病伴有腹痛而入院的 57 岁患者。经 Western 印迹检测呈阳性,确诊为艾滋病病毒感染者。他最初的 CD4 细胞计数为 270 cells/µL。外周淋巴结的组织学检查结果表明,KS与MCD有关。在同一名患者身上发现的这两种病症凸显了 HHV-8 的恶性潜能,尤其是在艾滋病毒诱发免疫缺陷的情况下。
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