Evaluation of mucin changes between daily and extended wear silicone hydrogel contact lenses

Rio Rhendy, Tri Rahayu, L. Edwar, Mohamad Sadikin, A. Kekalih
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Abstract

Background: Initially, contact lenses were recommended only for daily wear because of infection and discomfort concerns. With rising demand, particularly for overnight use, extended wear lenses have gained significance. Despite concerns, intensive development of materials like Lotrafilcon B aims to meet this demand, focusing on comfort and safety.Aim: This study aimed to evaluate the mucin quantity and quality changes between daily and extended wear (Lotrafilcon B), impacting eye health and comfort.Setting: The study was conducted at Kirana Eye Center, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Methods: This study was a single-blinded randomised clinical trial with two parallel groups. Forty (40) eligible subjects willingly participated. Mucin 5AC (MUC5AC) and Ferning-type tests were conducted. The 40 subjects with moderate myopia were then divided into a daily wear and an extended wear group. The MUC5AC test was performed at pre-fitting and at 4 weeks, whereas the Ferning-type tests were taken at pre-fitting and 1st and 4th weeks.Results: For both groups, there was a significant increase in MUC5AC levels from pre-fitting to week four, but with no significant difference between them in final MUC5AC levels. Additionally, the comparison of eyes with normal and abnormal Ferning-types between the two groups showed no significant differences at pre-fitting, 1st and 4th weeks.Conclusion: There is no significant difference in MUC5AC levels with the use of daily or extended wear (with Lotrafilcon B).Contribution: This study compares the impact of daily and extended wear Lotrafilcon B contact lenses on eye health and comfort in moderate myopia patients.
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评估日抛型和延展型硅水凝胶隐形眼镜的粘蛋白变化
背景:最初,出于感染和不适的考虑,隐形眼镜只被推荐用于日戴。随着需求的增加,尤其是对过夜隐形眼镜需求的增加,长时间配戴隐形眼镜变得越来越重要。目的:本研究旨在评估日抛型和延时型隐形眼镜(Lotrafilcon B)之间粘蛋白数量和质量的变化对眼睛健康和舒适度的影响:研究在印度尼西亚雅加达 Cipto Mangunkusumo 医院的 Kirana 眼科中心进行:这项研究是一项单盲随机临床试验,分为两个平行组。40名符合条件的受试者自愿参加。进行了粘蛋白 5AC (MUC5AC) 和费宁型测试。然后,40 名中度近视受试者被分为每日配戴组和长期配戴组。MUC5AC 测试在配戴前和配戴 4 周时进行,而 Ferning 型测试则在配戴前、配戴第 1 周和第 4 周时进行:结果:两组的 MUC5AC 含量从配戴前到第四周都有显著增加,但最终的 MUC5AC 含量没有明显差异。此外,对比两组正常和异常Ferning-type的眼睛,发现在配戴前、第1周和第4周没有明显差异:结论:每日佩戴或长期佩戴(使用 Lotrafilcon B)对 MUC5AC 水平没有明显影响:本研究比较了中度近视患者每日配戴和长期配戴 Lotrafilcon B 隐形眼镜对眼睛健康和舒适度的影响。
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来源期刊
African Vision and Eye Health
African Vision and Eye Health Health Professions-Optometry
CiteScore
1.00
自引率
0.00%
发文量
46
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