A Novel Four-Gene Signature Based on Nonsense-Mediated RNA Decay for Predicting Prognosis in Hepatocellular Carcinoma: Bioinformatics Analysis and Functional Validation
Jiaxin Zhao, Cheng Wang, Liang Zhao, Huiying Zhou, Rui Wu, Tao Zhang, Jiawei Ding, Junjie Zhou, Huilin Zheng, Lei Zhang, Tianci Kong, Jie Zhou, Zhenhua Hu
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Abstract
Purpose: Nonsense-mediated RNA decay (NMD), a surveillance pathway for selective degradation of aberrant mRNAs, is associated with cancer progression. Its potential as a predictor for aggressive hepatocellular carcinoma (HCC) is unclear. Here, we present an innovative NMD risk model for predicting HCC prognosis
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