Reference Value Fibrin Monomer in Healthy Children: A Cross-Sectional Study

IF 2.3 4区医学 Q2 HEMATOLOGY Clinical and Applied Thrombosis/Hemostasis Pub Date : 2024-04-24 DOI:10.1177/10760296241247560

Ta Anh Tuan, Tran Dang Xoay, Tran Thi Kieu My, Nguyen Thi Duyen, Nguyen Thi Trang, Nguyen Tat Kien, Chu Thanh Son, Nguyen Van Thang, Thieu Quang Quan, Dau Viet Hung

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Abstract

The objective of this study is to determine the fibrin monomer reference intervals in healthy children. This cross-sectional study was conducted in the Hematology Department at Vietnam National Children's Hospital (April 2023 to March 2024). Children without prior history of clotting disorders or anticoagulants use hospitalized in preparation for orthopedic surgery or inguinal hernia surgery were enrolled in the study. The fibrin monomer test method was the quantitative fibrin monomer test on the STA-R system (Diagnostica Stago™, France). Eighty-six children (58 males and 28 females) were enrolled in the study. The median (interquartile range, 2.5th-97.5th) fibrin monomer value of the study subjects was 2.56 (0.11-5.93) µg/mL, with no statistically significant difference in fibrin monomer values among the age groups of 1 month to 3 years, 3 years to 13 years, and 13 years to 18 years. This is the first study conducted in Vietnam to determine reference values of fibrin monomer in children. This information can help in the diagnosis and treatment of early hypercoagulation stage and disseminated intravascular coagulation in children.

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健康儿童的纤维蛋白单体参考值：一项横断面研究

本研究旨在确定健康儿童的纤维蛋白单体参考区间。这项横断面研究在越南国家儿童医院血液科进行（2023 年 4 月至 2024 年 3 月）。参加研究的儿童既往没有凝血功能障碍病史，也未使用过抗凝剂，住院是为了准备骨科手术或腹股沟疝气手术。纤维蛋白单体测试方法是在 STA-R 系统（法国 Diagnostica Stago™）上进行定量纤维蛋白单体测试。研究共招募了 86 名儿童（58 名男性和 28 名女性）。研究对象的纤维蛋白单体中位值（四分位间范围，2.5th-97.5th）为2.56（0.11-5.93）微克/毫升，1个月至3岁、3岁至13岁和13岁至18岁年龄组的纤维蛋白单体值差异无统计学意义。这是越南首次开展的确定儿童纤维蛋白单体参考值的研究。这些信息有助于诊断和治疗儿童早期高凝阶段和弥散性血管内凝血。

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来源期刊

Clinical and Applied Thrombosis/Hemostasis 医学-外周血管病

CiteScore

4.40

自引率

3.40%

发文量

150

审稿时长

2 months

期刊介绍： CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.