Inhaled magnesium versus inhaled salbutamol in rescue treatment for moderate and severe asthma exacerbations in pediatric patients

IF 2.8 4区医学 Q1 PEDIATRICS Jornal de pediatria Pub Date : 2024-04-30 DOI:10.1016/j.jped.2024.03.012

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Abstract

Objective

To compare the effectiveness of inhaled Magnesium Sulfate associated with Salbutamol versus Inhaled Salbutamol alone in patients with moderate and severe asthma exacerbations.

Method

Clinical, prospective and randomized study with patients between 3 and 14 years of age divided into two groups: one to receive inhaled salbutamol associated with magnesium sulfate (GSM), the other to receive inhaled salbutamol alone (GS). The sample consisted of 40 patients, 20 patients in each group. Severity was classified using the modified Wood-Downes score, with values between 4 and 7 classified as moderate and 8 or more classified as severe.

Results

Post-inhalation scores decreased both in patients who received salbutamol and magnesium and in those who received salbutamol alone, with no statistically significant difference between the groups.

Conclusions

Despite the benefits when administered intravenously, inhalation of the drug alone or in combination did not reduce the severity of the exacerbation.

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吸入镁与吸入沙丁胺醇在儿童患者中度和重度哮喘加重的抢救治疗中的比较

比较吸入硫酸镁联合舒喘宁与单独吸入舒喘宁对中度和重度哮喘加重患者的疗效。该临床前瞻性随机研究将 3 至 14 岁的患者分为两组：一组接受吸入舒喘宁联合硫酸镁（GSM），另一组接受单独吸入舒喘宁（GS）。样本包括 40 名患者，每组 20 人。严重程度采用改良的伍德-多恩斯评分法进行分类，评分值在 4 到 7 之间的为中度，评分值在 8 或以上的为重度。吸入沙丁胺醇和镁的患者以及仅吸入沙丁胺醇的患者吸入后的评分均有所下降，但两组之间的差异在统计学上并无显著性。尽管静脉给药有好处，但单独或联合吸入药物并不能减轻病情恶化的严重程度。

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来源期刊

Jornal de pediatria 医学-小儿科

CiteScore

5.60

自引率

3.00%

发文量

审稿时长

43 days

期刊介绍： Jornal de Pediatria is a bimonthly publication of the Brazilian Society of Pediatrics (Sociedade Brasileira de Pediatria, SBP). It has been published without interruption since 1934. Jornal de Pediatria publishes original articles and review articles covering various areas in the field of pediatrics. By publishing relevant scientific contributions, Jornal de Pediatria aims at improving the standards of pediatrics and of the healthcare provided for children and adolescents in general, as well to foster debate about health.