Antimicrobial Peptides (AMPs): New Perspectives on Their Function in Dermatological Diseases

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-04-30 DOI:10.1007/s10989-024-10609-7

Chou-Yi Hsu, Aseel Muthana Yousif, Khairia Abdulrahman Abullah, Huda Hayder Abbas, Hijaz Ahmad, Gaber E. Eldesoky, Mohaned Adil, Zeanb Hussein

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Abstract

Antimicrobial peptides (AMPs) are small cationic or amphipathic molecules that are produced by both prokaryotic and eukaryotic species. The latest findings in the field of dermatology point to the potential significance of AMPs in the battle against skin microbial infections. AMPs additionally function as multifunctional immune effectors, promoting angiogenesis, wound healing, and the production of cytokines and chemokines. In human skin, AMPs such as β-defensin, S100, and cathelicidin are primarily secreted by keratinocytes, neutrophils, sebocytes, or sweat glands. These substances are either produced continuously or expressed in reaction to certain inflammatory stimuli, thus playing a role in the development of various skin diseases in humans. Furthermore, in contrast to other human skin conditions, the level of AMP synthesis decreases as the disease progresses. In this review, we provide data supporting the role of AMPs as natural mediators of dermatological problems, as well as their potential for being used as therapeutic agents in the treatment of skin diseases.

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抗菌肽 (AMPs)：皮肤病中抗菌肽功能的新视角

抗菌肽（AMPs）是由原核生物和真核生物产生的阳离子或两性离子小分子。皮肤病学领域的最新研究结果表明，AMPs 在抗击皮肤微生物感染方面具有潜在意义。此外，AMPs 还具有多功能免疫效应器的功能，可促进血管生成、伤口愈合以及细胞因子和趋化因子的产生。在人体皮肤中，β-防御素、S100 和 cathelicidin 等 AMPs 主要由角质形成细胞、中性粒细胞、皮脂腺或汗腺分泌。这些物质或持续产生，或在某些炎症刺激下表达，因此在人类各种皮肤病的发病过程中发挥了作用。此外，与其他人类皮肤病不同的是，AMP 的合成水平会随着病情的发展而降低。在这篇综述中，我们提供的数据支持了 AMPs 作为皮肤病天然介质的作用，以及其作为治疗剂用于治疗皮肤病的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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