The risky business of ADP-ribosylating telomeric DNA

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Nature Structural & Molecular Biology Pub Date : 2024-05-07 DOI:10.1038/s41594-024-01285-8

Ylli Doksani, Francisca Lottersberger

引用次数: 0

Abstract

ADP-ribosylation regulates the activity of numerous proteins involved in the DNA damage response and repair. A new study shows that telomeric DNA can be ADP-ribosylated by PARP1, and prompt removal of the ADP-ribose by TARG1 is essential to preserve telomere integrity, unveiling DNA–ADP-ribosylation as a novel player in telomere stability.

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ADP-核糖基化端粒 DNA 的风险业务

ADP-核糖基化调节着许多参与DNA损伤反应和修复的蛋白质的活性。一项新的研究表明，端粒DNA可被PARP1进行ADP-核糖化，而TARG1及时清除ADP-核糖对保持端粒完整性至关重要，这揭示了DNA-ADP-核糖化是端粒稳定性的一个新角色。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.

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