Decapping NAD-RNAs: TIR domain-containing proteins stand out for specificity

IF 11.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Trends in Biochemical Sciences Pub Date : 2024-06-01 DOI:10.1016/j.tibs.2024.04.004

Dechang Cao

引用次数: 0

Abstract

A recently characterized RNA modification is NAD⁺-modified RNAs (NAD-RNAs). Various enzymes decap NAD-RNAs, and Wang and Yu et al. now describe another, namely Toll/interleukin-1 receptor (TIR) domain-containing proteins of bacteria and Archaea. TIR decapping products are a specific variant of cyclic ADP ribose (ADPR)-RNAs (v-cADPR-RNAs), opening a new window to the NAD-RNA world.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

为 NAD-RNA 解旋：含 TIR 结构域的蛋白质具有突出的特异性。

最近发现的一种 RNA 修饰是 NAD+ 修饰 RNA（NAD-RNA）。现在，Wang 和 Yu 等人描述了另一种酶，即细菌和古细菌的含 Toll/interleukin-1 受体（TIR）结构域的蛋白。TIR 脱帽产物是环状 ADP 核糖（ADPR）-RNA（v-cADPR-RNA）的一种特殊变体，为 NAD-RNA 世界打开了一扇新窗口。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.

期刊最新文献

ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising. TEX264-mediated selective autophagy directs DNA damage repair. Eph receptor signaling complexes in the plasma membrane. Endomembrane GPCR signaling: 15 years on, the quest continues. NMR spectroscopy reveals insights into mechanisms of GPCR signaling.