Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-11 DOI:10.1097/WAD.0000000000000613

Emilia Brandt, Anne Koivisto, Pedro Pereira, Ella Mustanoja, Petri Auvinen, Toni Saari, Juha-Matti Lehtola, Sanna Hannonen, Minna Rusanen, Ville Leinonen, Filip Scheperjans, Virve Kärkkäinen

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Abstract

Background: The gut microbiome is a complex system within the human gastrointestinal tract. The bacteria play a significant role in human health, and some can promote inflammation and pathologic processes through chemical interactions or metabolites. Gut microbiome dysbiosis has been linked to some neurological and other diseases. Here we aimed to examine microbiome differences between patients with a progressive neurological disorder, idiopathic normal pressure hydrocephalus (iNPH), compared with healthy controls (CO).

Methods: We recruited 37 neurologically healthy CO and 10 patients with shunted iNPH. We evaluated these participants' cognition using the CERAD-NB test battery and CDR test, and collected a variety of information, including about dietary habits and health. We also collected fecal samples, which were subjected to 16S amplicon sequencing to analyze differences in gut microbiome composition.

Results: We found that the iNPH group exhibited significantly different abundances of 10 bacterial genera compared with the CO group. The Escherichia/Shigella and Anaeromassilibacillus genera were most remarkably increased. Other increased genera were Butyrivibrio , Duncaniella , and an unidentified genus. The decreased genera were Agathobaculum , Paramuribaculum , Catenibacterium , and 2 unidentified genera.

Conclusions: Here we report the first identified microbiome differences in iNPH patients compared with healthy controls.

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特发性正常压力脑积水患者肠道微生物组的变化

背景：肠道微生物组是人体胃肠道内的一个复杂系统。细菌对人体健康起着重要作用，有些细菌会通过化学作用或代谢产物促进炎症和病理过程。肠道微生物群失调与一些神经系统疾病和其他疾病有关。在此，我们旨在研究一种进行性神经系统疾病--特发性正常压力脑积水（iNPH）患者与健康对照组（CO）之间微生物组的差异：我们招募了 37 名神经系统健康的 CO 和 10 名分流的 iNPH 患者。我们使用 CERAD-NB 测试和 CDR 测试评估了这些参与者的认知能力，并收集了包括饮食习惯和健康状况在内的各种信息。我们还收集了粪便样本，并对样本进行了 16S 扩增子测序，以分析肠道微生物组组成的差异：结果：我们发现，与 CO 组相比，iNPH 组 10 个细菌属的丰度有显著差异。其中，埃希氏菌/志贺氏菌和厌氧菌属的增加最为明显。其他增加的菌属有布氏酵母菌属、邓氏酵母菌属和一个未确定的菌属。减少的属有 Agathobaculum、Paramuribaculum、Catenibacterium 和 2 个未确定的属：我们在此报告了首次发现的 iNPH 患者与健康对照组相比微生物组的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.