A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient.

IF 1.3 Q4 RESPIRATORY SYSTEM Lung India Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI:10.4103/lungindia.lungindia_221_23
Richa Mishra, Ashima Jamwal, Bishal Gupta, Sudeep Kumar, Abhijeet Bharali, Parijat Das, Alok Nath, Manoj Jain, Zafar Neyaz
{"title":"A rare case of isoniazid mono-resistant tuberculosis presenting as cardiac tamponade along with an anterior mediastinal mass in a 15-year-old immunocompetent patient.","authors":"Richa Mishra, Ashima Jamwal, Bishal Gupta, Sudeep Kumar, Abhijeet Bharali, Parijat Das, Alok Nath, Manoj Jain, Zafar Neyaz","doi":"10.4103/lungindia.lungindia_221_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan revealed a heterogeneously enhancing lesion in the anterior mediastinum with multiple discrete lymph nodes in the cervical and mediastinal locations. The GeneXpert MTB/RIF assay performed on the CT-guided biopsy of the mass was negative, but the culture for Mycobacterium tuberculosis was positive at 7 weeks of incubation. There was a suboptimal radiological response after 6 months of treatment. First-line drug susceptibility testing (DST) performed by line probe assay (LPA) on the positive culture detected high-level resistance to isoniazid. The treatment was modified as per DST results to which the patient responded well.</p>","PeriodicalId":47462,"journal":{"name":"Lung India","volume":"41 2","pages":"130-134"},"PeriodicalIF":1.3000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959313/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lung India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/lungindia.lungindia_221_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract: A 15-year-old boy presented with a sudden onset of breathlessness for 7 days, gradual loss of weight of 17.6 lbs over the last month and progressive hoarseness of voice for 7 months. The contrast-enhanced computed tomography (CECT) scan revealed a heterogeneously enhancing lesion in the anterior mediastinum with multiple discrete lymph nodes in the cervical and mediastinal locations. The GeneXpert MTB/RIF assay performed on the CT-guided biopsy of the mass was negative, but the culture for Mycobacterium tuberculosis was positive at 7 weeks of incubation. There was a suboptimal radiological response after 6 months of treatment. First-line drug susceptibility testing (DST) performed by line probe assay (LPA) on the positive culture detected high-level resistance to isoniazid. The treatment was modified as per DST results to which the patient responded well.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
一例罕见的单耐药异烟肼结核病病例,患者 15 岁,免疫功能正常,表现为心脏填塞和前纵隔肿块。
摘要:一名15岁男孩突然出现呼吸困难7天,近一个月来体重逐渐减轻17.6磅,声音逐渐嘶哑7个月。造影剂增强计算机断层扫描(CECT)显示,前纵隔有异质性增强病灶,颈部和纵隔位置有多个离散淋巴结。在CT引导下对肿块进行活检时,基因Xpert MTB/RIF检测结果为阴性,但经7周培养后,结核分枝杆菌培养结果呈阳性。治疗 6 个月后,放射学反应不理想。用线探针检测法(LPA)对阳性培养物进行了一线药敏试验(DST),检测出了对异烟肼的高度耐药性。根据 DST 结果对治疗进行了调整,患者反应良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Lung India
Lung India RESPIRATORY SYSTEM-
CiteScore
2.30
自引率
12.50%
发文量
114
审稿时长
37 weeks
期刊最新文献
"Stoned" airways: Bilateral airway foreign body (pebble) aspiration following a road traffic accident. An uncommon cause of acute hypercapnic respiratory failure managed with endoscopic ultrasound. Bronchial anthracofibrosis beyond bronchial involvement causing pulmonary artery stenosis. Bronchodilator reversibility and eosinophilic biomarkers in chronic obstructive pulmonary disease patients. Case series of Y shaped self-expanding metallic stents (Y-SEMS) for central airway obstruction - Experience of deployment with 'Single Guide Wire' technique.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1