Pleiotrophin serum level and metastasis occurrence in breast cancer patients.

Breast disease Pub Date : 2024-01-01 DOI:10.3233/BD-249003

Muhamad Ikhlas, Djonny Ferianto, Salman Ardi Syamsu, Idham Jaya Ganda, Nilam Smaradania, Elridho Sampepajung, Citra Azma Anggita, Muhammad Faruk

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Abstract

Background: Breast cancer (BC) cases in Makassar, Indonesia, are on the rise, with 2723 cases recorded in 2018. Tumor cells in the blood indicate metastasis, emphasizing the need for early diagnosis and monitoring. Pleiotrophin (PTN) is associated with various human malignancies, and recent studies suggest a correlation between PTN expression and advanced BC stages; therefore, PTN could serve as an independent predictor of metastasis. This study aimed to determine the correlation between serum PTN level, histopathological grading, and metastasis occurrence in BC patients in Makassar, Indonesia.

Methods: This study used an observational cross-sectional design. Pleiotrophin serum levels were examined using enzyme-linked immunosorbent assays. This study used a t-test and ROC curve analysis for the statistical tests.

Results: Of the 64 samples used in this study, metastasis was present in 26 cases and absent in 38 samples. The mean PTN serum levels in metastatic and non-metastatic breast cancer patients were 4.311 and 1.253, respectively. The PTN receiver operating characteristic curve showed an area under the curve of 2.47 ng/dL, which was statistically significant (p < 0.001). A significant relationship was found between PTN level and metastasis (p < 0.001). The correlation coefficient was 0.791, indicating a positive correlation.

Conclusion: This study revealed that the serum PTN level among breast cancer patients had a cut-off value of 2.47 ng/dL. The research established a clear correlation between PTN level and metastasis occurrence in breast cancer patients, indicating a higher likelihood of distant metastasis with elevated PTN concentration.

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乳腺癌患者的Pleiotrophin血清水平与转移发生率

背景：印度尼西亚望加锡的乳腺癌（BC）病例呈上升趋势，2018年记录在案的病例为2723例。血液中的肿瘤细胞预示着转移，强调了早期诊断和监测的必要性。Pleiotrophin（PTN）与多种人类恶性肿瘤有关，最近的研究表明，PTN表达与BC晚期之间存在相关性；因此，PTN可作为转移的独立预测因子。本研究旨在确定印尼望加锡 BC 患者血清 PTN 水平、组织病理学分级和转移发生率之间的相关性：本研究采用观察性横断面设计。方法：本研究采用观察性横断面设计，使用酶联免疫吸附试验检测PTN血清水平。本研究采用 t 检验和 ROC 曲线分析进行统计检验：结果：在本研究使用的 64 份样本中，26 例存在转移，38 例没有转移。转移性和非转移性乳腺癌患者血清中 PTN 的平均水平分别为 4.311 和 1.253。PTN 接收者操作特征曲线显示曲线下面积为 2.47 ng/dL，具有统计学意义（P < 0.001）。PTN 水平与转移之间存在明显关系（P < 0.001）。相关系数为 0.791，表明两者呈正相关：本研究显示，乳腺癌患者血清 PTN 水平的临界值为 2.47 ng/dL。研究结果表明，乳腺癌患者的 PTN 水平与转移发生率之间存在明显的相关性，表明 PTN 浓度升高时发生远处转移的可能性更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast disease Medicine-Oncology

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： The recent expansion of work in the field of breast cancer inevitably will hasten discoveries that will have impact on patient outcome. The breadth of this research that spans basic science, clinical medicine, epidemiology, and public policy poses difficulties for investigators. Not only is it necessary to be facile in comprehending ideas from many disciplines, but also important to understand the public implications of these discoveries. Breast Disease publishes review issues devoted to an in-depth analysis of the scientific and public implications of recent research on a specific problem in breast cancer. Thus, the reviews will not only discuss recent discoveries but will also reflect on their impact in breast cancer research or clinical management.