The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review.

IF 3.6 3区医学 Q1 PSYCHIATRY Revista Brasileira de Psiquiatria Pub Date : 2024-01-01 Epub Date: 2023-12-20 DOI:10.47626/1516-4446-2023-3267

Mohammad Ali, Renata Husnudinov, Bianca Wollenhaupt-Aguiar, Benicio N Frey

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Abstract

Objectives: Evidence from diffusion tensor imaging (DTI) and postmortem studies has demonstrated white-matter (WM) deficits in bipolar disorder (BD). Changes in peripheral blood biomarkers have also been observed; however, studies evaluating the potential relationship between brain alterations and the periphery are scarce. The objective of this systematic review is to investigate the relationship between blood-based biomarkers and WM in BD.

Methods: PubMed, Embase, and PsycINFO were used to conduct literature searches. Cross-sectional or longitudinal studies reporting original data which investigated both a blood-based biomarker and WM (by neuroimaging) in BD were included.

Results: Of 3,750 studies retrieved, 23 were included. Several classes of biomarkers were found to have a significant relationship with WM in BD. These included cytokines and growth factors (interleukin-8 [IL-8], tumor necrosis factor alpha [TNF-a], and insulin-like growth factor binding protein 3 [IGFBP-3]), innate immune system (natural killer cells [NK]), metabolic markers (lipid hydroperoxidase, cholesterol, triglycerides), the kynurenine (Kyn) pathway (5-hydroxyindoleacetic acid, kynurenic acid [Kyna]), and various gene polymorphisms (serotonin-transporter-linked promoter region).

Conclusion: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.

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血液生物标志物与双相情感障碍患者脑白质和髓鞘含量的关系：系统综述。

目的：弥散张量成像（DTI）和尸检研究的证据表明，双相情感障碍（BD）患者存在白质（WM）缺陷。此外，还观察到外周血生物标志物的变化；然而，评估大脑变化与外周血之间潜在关系的研究却很少。本系统综述旨在研究 BD 患者血液生物标志物与 WM 之间的关系：方法：使用 PubMed、Embase 和 PsycINFO 进行文献检索。方法：使用PubMase、Embase和PsycINFO进行文献检索，纳入报告原始数据的横断面或纵向研究，这些研究同时调查了BD中基于血液的生物标志物和WM（通过神经影像学）：结果：在检索到的 3,750 项研究中，有 23 项被纳入。结果：在检索到的 3,750 项研究中，有 23 项被纳入。研究发现，有几类生物标志物与 BD 患者的 WM 有显著关系。其中包括细胞因子和生长因子（白细胞介素-8 [IL-8]、肿瘤坏死因子α [TNF-a] 和胰岛素样生长因子结合蛋白 3 [IGFBP-3]）、先天免疫系统（自然杀伤细胞 [NK]）、代谢标记物（脂质氢化代谢标志物（脂质过氧化氢酶、胆固醇、甘油三酯）、犬尿氨酸（Kyn）途径（5-羟基吲哚乙酸、犬尿氨酸 [Kyna]）以及各种基因多态性（与血清素转运体相连的启动子区域）。结论本系统综述揭示了基于血液的生物标记物与在 BD 中观察到的 WM 缺陷标记物相关。我们鼓励对这些特定生物标志物的潜在临床效用进行纵向研究。

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来源期刊

Revista Brasileira de Psiquiatria 医学-精神病学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Revista Brasileira de Psiquiatria (RBP) is the official organ of the Associação Brasileira de Psiquiatria (ABP - Brazilian Association of Psychiatry). The Brazilian Journal of Psychiatry is a bimonthly publication that aims to publish original manuscripts in all areas of psychiatry, including public health, clinical epidemiology, basic science, and mental health problems. The journal is fully open access, and there are no article processing or publication fees. Articles must be written in English.