Opportunities and challenges in phage therapy for cardiometabolic diseases.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-04-17 DOI:10.1016/j.tem.2024.03.007
Koen Wortelboer, Hilde Herrema
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Abstract

The worldwide prevalence of cardiometabolic diseases (CMD) is increasing, and emerging evidence implicates the gut microbiota in this multifactorial disease development. Bacteriophages (phages) are viruses that selectively target a bacterial host; thus, phage therapy offers a precise means of modulating the gut microbiota, limiting collateral damage on the ecosystem. Several studies demonstrate the potential of phages in human disease, including alcoholic and steatotic liver disease. In this opinion article we discuss the potential of phage therapy as a predefined medicinal product for CMD and discuss its current challenges, including the generation of effective phage combinations, product formulation, and strict manufacturing requirements.

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噬菌体疗法治疗心脏代谢疾病的机遇与挑战。
全球范围内心脏代谢疾病(CMD)的发病率正在上升,而新出现的证据表明,肠道微生物群与这种多因素疾病的发生有关。噬菌体(噬菌体)是一种选择性针对细菌宿主的病毒;因此,噬菌体疗法提供了一种精确调节肠道微生物群的方法,限制了对生态系统的附带损害。多项研究证明了噬菌体在人类疾病(包括酒精性肝病和脂肪肝)中的潜力。在这篇观点文章中,我们讨论了噬菌体疗法作为治疗慢性阻塞性肺病的预定义药物的潜力,并讨论了其目前面临的挑战,包括生成有效的噬菌体组合、产品配方和严格的生产要求。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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