Toward the "Perfect" Shunt: Historical Vignette, Current Efforts, and Future Directions.

Anthony Podgoršak, Fabian Flürenbrock, Nina Eva Trimmel, Leonie Korn, Markus Florian Oertel, Lennart Stieglitz, Sandra Fernandes Dias, Melanie Michaela Hierweger, Melanie Zeilinger, Miriam Weisskopf, Marianne Schmid Daners
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Abstract

As a concept, drainage of excess fluid volume in the cranium has been around for more than 1000 years. Starting with the original decompression-trepanation of Abulcasis to modern programmable shunt systems, to other nonshunt-based treatments such as endoscopic third ventriculostomy and choroid plexus cauterization, we have come far as a field. However, there are still fundamental limitations that shunts have yet to overcome: namely posture-induced over- and underdrainage, the continual need for valve opening pressure especially in pediatric cases, and the failure to reinstall physiologic intracranial pressure dynamics. However, there are groups worldwide, in the clinic, in industry, and in academia, that are trying to ameliorate the current state of the technology within hydrocephalus treatment. This chapter aims to provide a historical overview of hydrocephalus, current challenges in shunt design, what members of the community have done and continue to do to address these challenges, and finally, a definition of the "perfect" shunt is provided and how the authors are working toward it.

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迈向 "完美 "分流器:历史剪影、当前努力和未来方向。
作为一个概念,颅内多余液体的引流已有 1000 多年的历史。从最初的阿布卡西减压-换流术到现代可编程分流系统,再到其他非分流治疗方法,如内镜下第三脑室造口术和脉络丛烧灼术,我们在这一领域已经取得了长足的进步。然而,分流术仍有一些根本性的局限性尚待克服:即体位引起的过度引流和引流不足、持续的阀门开启压力需求(尤其是在儿科病例中)以及无法恢复生理颅内压动态。不过,世界各地的临床、工业和学术团体都在努力改善脑积水治疗技术的现状。本章旨在概述脑积水的历史、目前分流器设计所面临的挑战、社区成员为应对这些挑战已经完成并将继续开展的工作,最后提供 "完美 "分流器的定义以及作者如何为实现这一目标而努力。
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