Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?

Enfermedades infecciosas y microbiologia clinica (English ed.) Pub Date : 2024-10-01 Epub Date: 2024-05-04 DOI:10.1016/j.eimce.2024.02.013

Marta Díaz-Navarro, Rama Hafian, María Jesús Pérez-Granda, Emilia Cercenado, Patricia Muñoz, María Guembe

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Abstract

Introduction: The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage.

Methods: We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin (D) against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for D before and during storage under freezing up to 6 months.

Results: Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in Staphylococcus epidermidis between DH and D (97.6 vs. 100, p=0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between D and DH solutions.

Conclusion: The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.

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解决导管锁定疗法：肝素与达巴万星一起在溶液中冷冻时是否会降低达巴万星的生物活性？

简介我们的研究小组曾证实达巴万星可用作导管锁定溶液。然而，我们需要评估肝素在冷冻储存期间是否会影响达巴万星的生物活性：我们测试了达巴万星+肝素（DH）与达巴万星（D）对葡萄球菌生物膜的生物活性，比较了 DH 与 D 在冷冻前和冷冻储存长达 6 个月期间获得的 cfu 计数和代谢活性的中值：结果：尽管在第 3 个月时，DH 和 D 的表皮葡萄球菌代谢活性降低的中位数百分比略有下降（97.6 对 100，p=0.037），但考虑到临床标准，在实验结束时，D 和 DH 溶液的任何测试变量均未观察到显著降低：结论：在达巴万星锁定溶液中添加肝素不会影响其对葡萄球菌生物膜的生物活性，无论其在冷冻条件下的保存时间长短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enfermedades infecciosas y microbiologia clinica (English ed.)

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