Germline and somatic mutations in prostate cancer: Implications for treatment

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-05-08 DOI:10.1016/j.currproblcancer.2024.101101
Cameron Chalker, Brie Chun, Alexandra O. Sokolova
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Abstract

Genetic testing is an integral part of the workup of metastatic prostate cancer, in part, because the results can have a profound impact on the subsequent management of this disease. There are now several Food & Drug Administration (FDA) approved therapeutics available for patients with prostate cancer and certain genetic abnormalities – most notably, mutations in DNA damage repair (DDR) pathways such mismatch repair (MMR) and homologous recombination repair (HRR). In this review of the current literature, we discuss the indications for somatic and germline testing, the genetic changes of particular clinical relevance, the associated therapeutic options, and the clinical data supporting their use. We also highlight select trials-in-progress and future directions for the field

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前列腺癌中的种系突变和体细胞突变:对治疗的影响
基因检测是转移性前列腺癌检查中不可或缺的一部分,部分原因是检测结果会对该疾病的后续治疗产生深远影响。目前有几种经美国食品药品监督管理局(FDA)批准的治疗方法可用于前列腺癌和某些基因异常的患者,其中最值得注意的是DNA损伤修复(DDR)途径中的突变,如错配修复(MMR)和同源重组修复(HRR)。在这篇现有文献综述中,我们讨论了体细胞和种系检测的适应症、与临床特别相关的基因变化、相关的治疗方案以及支持其使用的临床数据。我们还重点介绍了正在进行的部分试验和该领域的未来发展方向
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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