Assessment of 3D hemi-diaphragmatic motion via free-breathing dynamic MRI in pediatric thoracic insufficiency syndrome

Mahdie Hosseini, Jayaram K. Udupa, You Hao, Yubing Tong, Caiyun Wu, Yusuf Akhtar, Mostafa Al-Noury, Shiva Shaghaghi, Joseph M. McDonough, David M. Biko, Samantha Gogel, Oscar H. Mayer, Patrick J. Cahill, Drew A. Torigian, Jason B. Anari
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Abstract

Purpose Thoracic insufficiency syndrome (TIS) affects ventilatory function due to spinal and thoracic deformities limiting lung space and diaphragmatic motion. Corrective orthopedic surgery can be used to help normalize skeletal anatomy, restoring lung space and diaphragmatic motion. This study employs free-breathing dynamic MRI (dMRI) and quantifies the 3D motion of each hemi-diaphragm surface in normal and TIS patients, and evaluates effects of surgical intervention.
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通过自由呼吸动态磁共振成像评估小儿胸廓发育不全综合征的三维半膈运动
目的 胸廓发育不全综合征(TIS)会影响通气功能,原因是脊柱和胸廓畸形限制了肺部空间和膈肌运动。矫正矫形手术可帮助骨骼解剖恢复正常,恢复肺部空间和膈肌运动。本研究采用自由呼吸动态核磁共振成像(dMRI),量化正常和 TIS 患者每个半膈表面的三维运动,并评估手术干预的效果。
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