Generalized Periodic Discharges Associated With Catatonia and Delirium: A Case Series.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2024-01-01 Epub Date: 2024-05-09 DOI:10.1176/appi.neuropsych.20230174

James Luccarelli, Joshua R Smith, Gregory Fricchione, M Brandon Westover

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Abstract

Objective: Generalized periodic discharges are a repeated and generalized electroencephalography (EEG) pattern that can be seen in the context of altered mental status. This article describes a series of five individuals with generalized periodic discharges who demonstrated signs and symptoms of catatonia, a treatable neuropsychiatric condition.

Methods: Inpatients with a clinical diagnosis of catatonia, determined with the Bush-Francis Catatonia Rating Scale (BFCRS), and EEG recordings with generalized periodic discharges were analyzed in a retrospective case series.

Results: Five patients with catatonia and generalized periodic discharges on EEG were evaluated from among 106 patients with catatonia and contemporaneous EEG measurements. Four of these patients showed an improvement in catatonia severity when treated with benzodiazepines, with an average reduction of 6.75 points on the BFCRS.

Conclusions: Among patients with generalized periodic discharges, catatonia should be considered, in the appropriate clinical context. Patients with generalized periodic discharges and catatonia may benefit from treatment with empiric trials of benzodiazepines.

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与紧张症和谵妄有关的全身周期性放电：病例系列。

目的：全身性周期性放电是一种重复和全身性的脑电图（EEG）模式，可在精神状态改变的情况下出现。本文描述了五名出现全身周期性放电的患者，他们表现出紧张症的症状和体征，紧张症是一种可治疗的神经精神疾病：方法：通过回顾性病例系列分析了临床诊断为紧张症的住院病人（根据布什-弗朗西斯紧张症评定量表（Bush-Francis Catatonia Rating Scale，BFCRS）确定）以及伴有全身周期性放电的脑电图记录：从 106 名患有紧张性精神障碍且当时进行了脑电图测量的患者中，评估了五名患有紧张性精神障碍且脑电图出现全身周期性放电的患者。其中四名患者在接受苯二氮卓治疗后，紧张症的严重程度有所改善，BFCRS平均降低了6.75分：结论：在全身性周期性放电患者中，应在适当的临床情况下考虑紧张症。全身性周期性放电和紧张症患者可能会受益于苯二氮卓类药物的经验性治疗。

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来源期刊

Journal of Neuropsychiatry and Clinical Neurosciences 医学-精神病学

CiteScore

5.30

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： As the official Journal of the American Neuropsychiatric Association, the premier North American organization of clinicians, scientists, and educators specializing in behavioral neurology & neuropsychiatry, neuropsychology, and the clinical neurosciences, the Journal of Neuropsychiatry and Clinical Neurosciences (JNCN) aims to publish works that advance the science of brain-behavior relationships, the care of persons and families affected by neurodevelopmental, acquired neurological, and neurodegenerative conditions, and education and training in behavioral neurology & neuropsychiatry. JNCN publishes peer-reviewed articles on the cognitive, emotional, and behavioral manifestations of neurological conditions, the structural and functional neuroanatomy of idiopathic psychiatric disorders, and the clinical and educational applications and public health implications of scientific advances in these areas. The Journal features systematic reviews and meta-analyses, narrative reviews, original research articles, scholarly considerations of treatment and educational challenges in behavioral neurology & neuropsychiatry, analyses and commentaries on advances and emerging trends in the field, international perspectives on neuropsychiatry, opinions and introspections, case reports that inform on the structural and functional bases of neuropsychiatric conditions, and classic pieces from the field’s rich history.