Gulafsha Kausar, Shashi B Chauhan, Ritirupa Roy, Shashi Kumar, Christian Engwerda, Susanne Nylen, Rajiv Kumar, Mary E Wilson, Shyam Sundar
{"title":"Apolipoprotein E Is Upregulated in Blood and Circulating Monocytes of Indian Patients With Visceral Leishmaniasis.","authors":"Gulafsha Kausar, Shashi B Chauhan, Ritirupa Roy, Shashi Kumar, Christian Engwerda, Susanne Nylen, Rajiv Kumar, Mary E Wilson, Shyam Sundar","doi":"10.1111/pim.13036","DOIUrl":null,"url":null,"abstract":"<p><p>Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson's disease, Alzheimer's and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with visceral leishmaniasis (VL) living in an endemic area in Bihar, India, and contrasted these with control healthy subjects or other diagnostic bone marrows from individuals in the same region. Samples from VL patients were obtained prior to initiating treatment. Our study revealed significant upregulated expression of the apoE transcript in patients with VL. Furthermore, the levels of ApoE protein were elevated in serum samples of subjects with VL compared with healthy endemic controls. These observations may provide clues regarding the complex interactions between lipid metabolism and immunoregulation of infectious and inflammatory diseases.</p>","PeriodicalId":19931,"journal":{"name":"Parasite Immunology","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141729/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/pim.13036","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Apolipoprotein E (ApoE) has been associated with several diseases including Parkinson's disease, Alzheimer's and multiple sclerosis. ApoE also has documented immunomodulatory functions. We investigated gene expression in circulating monocytes and in bone marrows of patients with visceral leishmaniasis (VL) living in an endemic area in Bihar, India, and contrasted these with control healthy subjects or other diagnostic bone marrows from individuals in the same region. Samples from VL patients were obtained prior to initiating treatment. Our study revealed significant upregulated expression of the apoE transcript in patients with VL. Furthermore, the levels of ApoE protein were elevated in serum samples of subjects with VL compared with healthy endemic controls. These observations may provide clues regarding the complex interactions between lipid metabolism and immunoregulation of infectious and inflammatory diseases.
载脂蛋白 E（ApoE）与多种疾病相关，包括帕金森病、阿尔茨海默氏症和多发性硬化症。载脂蛋白 E 还具有免疫调节功能。我们研究了生活在印度比哈尔邦流行区的内脏利什曼病（VL）患者循环单核细胞和骨髓中的基因表达，并将其与健康对照组或同一地区其他诊断性骨髓进行了对比。VL 患者的样本是在开始治疗前获得的。我们的研究发现，VL 患者体内载脂蛋白 E 转录本的表达明显升高。此外，与健康的地方病对照组相比，VL 患者血清样本中的载脂蛋白水平也有所升高。这些观察结果可能为传染性和炎症性疾病的脂质代谢与免疫调节之间复杂的相互作用提供了线索。
期刊介绍：
Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts. Emphasis has been placed on how hosts control parasites, and the immunopathological reactions which take place in the course of parasitic infections. The Journal welcomes original work on all parasites, particularly human parasitology, helminths, protozoa and ectoparasites.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
