Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY JBIC Journal of Biological Inorganic Chemistry Pub Date : 2024-05-10 DOI:10.1007/s00775-024-02055-z

Hiba Messaoudi, Göknur Yaşa Atmaca, Ayşegül Türkkol, Mehmet Dinçer Bilgin, Ali Erdoğmuş

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Abstract

This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the synthesized Schiff-base diaxially substituted silicon phthalocyanines. In photochemical studies, the singlet oxygen quantum yields (Φ_∆) were determined as 0.43 for Si1a, 0.94 for Q-Si1a, 0.58 for S-Si1a, and 0.49 for B-Sia1. In sono-photochemical studies, the Φ_∆ values were reached to 0.67 for Si1a, 1.06 for Q-Si1a, 0.65 for S-Si1a, and 0.67 for B-Sia1. In addition, this study demonstrates the therapeutic efficacy of phthalocyanines synthesized as sensitizers on the PC3 prostate cancer cell line through in vitro experiments. The application of these treatment modalities exhibited notable outcomes, leading to a substantial decrease in cell viability within the PC3 prostate cancer cell line. These findings highlight the potential of utilizing these synthesized phthalocyanines as promising therapeutic agents for prostate cancer treatment.

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通过声光化学研究和对前列腺癌细胞的体外活性监测新型希夫碱取代硅酞菁的单线态氧生成。

这项研究证明了声波光动力疗法的潜力，它是利用合成的希夫碱二轴取代硅酞菁提高单线态氧生成的一种有效方法。在光化学研究中，Si1a 的单线态氧量子产率（Φ∆）为 0.43，Q-Si1a 为 0.94，S-Si1a 为 0.58，B-Sia1 为 0.49。在声光化学研究中，Si1a 的 Φ∆ 值为 0.67，Q-Si1a 为 1.06，S-Si1a 为 0.65，B-Sia1 为 0.67。此外，本研究还通过体外实验证明了作为敏化剂合成的酞菁对 PC3 前列腺癌细胞系的治疗效果。这些治疗方法的应用效果显著，使 PC3 前列腺癌细胞系的细胞存活率大幅下降。这些发现凸显了利用这些合成的酞菁作为前列腺癌治疗剂的潜力。

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来源期刊

JBIC Journal of Biological Inorganic Chemistry 化学-生化与分子生物学

CiteScore

5.90

自引率

3.30%

发文量

审稿时长

3 months

期刊介绍： Biological inorganic chemistry is a growing field of science that embraces the principles of biology and inorganic chemistry and impacts other fields ranging from medicine to the environment. JBIC (Journal of Biological Inorganic Chemistry) seeks to promote this field internationally. The Journal is primarily concerned with advances in understanding the role of metal ions within a biological matrix—be it a protein, DNA/RNA, or a cell, as well as appropriate model studies. Manuscripts describing high-quality original research on the above topics in English are invited for submission to this Journal. The Journal publishes original articles, minireviews, and commentaries on debated issues.