Artificial intelligence applications for fault detection and diagnosis in pharmaceutical bioprocesses: a review

IF 8 2区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Current Opinion in Chemical Engineering Pub Date : 2024-05-11 DOI:10.1016/j.coche.2024.101025
Mohammad Aghaee , Abhishek Mishra , Stephane Krau , Ibrahim Melih Tamer , Hector Budman
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Abstract

Because of increasing demand and strict regulations, pharmaceutical manufacturers encounter significant hurdles in achieving high productivity while ensuring normal process states. Variability in raw materials and operational disturbances can lead to deviations from normal operating conditions that result in decreased productivity. The implementation of smart fault detection and diagnosis (FDD) techniques is crucial for attaining acceptable productivity and ensuring process safety. In this review, we identify the major challenges of smart FDD in pharmaceutical processes, and we discuss future opportunities and new perspectives.

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人工智能在制药生物工艺故障检测和诊断中的应用:综述
由于需求不断增长和法规日益严格,制药商在确保正常工艺状态的同时实现高生产率方面遇到了巨大障碍。原材料的多变性和操作干扰会导致偏离正常操作条件,从而降低生产率。实施智能故障检测和诊断 (FDD) 技术对于实现可接受的生产率和确保工艺安全至关重要。在本综述中,我们将指出智能故障检测与诊断技术在制药工艺中面临的主要挑战,并讨论未来的机遇和新的前景。
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来源期刊
Current Opinion in Chemical Engineering
Current Opinion in Chemical Engineering BIOTECHNOLOGY & APPLIED MICROBIOLOGYENGINE-ENGINEERING, CHEMICAL
CiteScore
12.80
自引率
3.00%
发文量
114
期刊介绍: Current Opinion in Chemical Engineering is devoted to bringing forth short and focused review articles written by experts on current advances in different areas of chemical engineering. Only invited review articles will be published. The goals of each review article in Current Opinion in Chemical Engineering are: 1. To acquaint the reader/researcher with the most important recent papers in the given topic. 2. To provide the reader with the views/opinions of the expert in each topic. The reviews are short (about 2500 words or 5-10 printed pages with figures) and serve as an invaluable source of information for researchers, teachers, professionals and students. The reviews also aim to stimulate exchange of ideas among experts. Themed sections: Each review will focus on particular aspects of one of the following themed sections of chemical engineering: 1. Nanotechnology 2. Energy and environmental engineering 3. Biotechnology and bioprocess engineering 4. Biological engineering (covering tissue engineering, regenerative medicine, drug delivery) 5. Separation engineering (covering membrane technologies, adsorbents, desalination, distillation etc.) 6. Materials engineering (covering biomaterials, inorganic especially ceramic materials, nanostructured materials). 7. Process systems engineering 8. Reaction engineering and catalysis.
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