Vaccinomics and adversomics: key elements for a personalized vaccinology.

IF 2.1 Q4 IMMUNOLOGY Clinical and Experimental Vaccine Research Pub Date : 2024-04-01 Epub Date: 2024-04-30 DOI:10.7774/cevr.2024.13.2.105
Antonio Laganà, Giuseppa Visalli, Angela Di Pietro, Alessio Facciolà
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Abstract

Vaccines are one of the most important and effective tools in the prevention of infectious diseases and research about all the aspects of vaccinology are essential to increase the number of available vaccines more and more safe and effective. Despite the unquestionable value of vaccinations, vaccine hesitancy has spread worldwide compromising the success of vaccinations. Currently, the main purpose of vaccination campaigns is the immunization of whole populations with the same vaccine formulations and schedules for all individuals. A personalized vaccinology approach could improve modern vaccinology counteracting vaccine hesitancy and giving great benefits for human health. This ambitious purpose would be possible by facing and deepening the areas of vaccinomics and adversomics, two innovative areas of study investigating the role of a series of variables able to influence the immune response to vaccinations and the development of serious side effects, respectively. We reviewed the recent scientific knowledge about these innovative sciences focusing on genetic and non-genetic basis involved in the individual response to vaccines in terms of both immune response and side effects.

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疫苗组学和逆境组学:个性化疫苗学的关键要素。
疫苗是预防传染病的最重要、最有效的工具之一,而疫苗学各方面的研究对于增加现有疫苗的数量、提高疫苗的安全性和有效性至关重要。尽管疫苗接种的价值毋庸置疑,但疫苗接种犹豫症却在全球蔓延,影响了疫苗接种的成功。目前,疫苗接种活动的主要目的是用相同的疫苗配方和接种程序对所有人群进行免疫接种。个性化疫苗接种方法可以改进现代疫苗接种方法,抵消疫苗接种的犹豫不决,为人类健康带来巨大益处。要实现这一宏伟目标,就必须正视并深化疫苗组学(vaccinomics)和逆境组学(adversomics)这两个创新的研究领域,这两个领域分别研究一系列能够影响疫苗免疫反应和严重副作用发生的变量的作用。我们回顾了有关这些创新科学的最新科学知识,重点是在免疫反应和副作用方面个人对疫苗反应所涉及的遗传和非遗传基础。
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来源期刊
CiteScore
3.70
自引率
3.70%
发文量
29
审稿时长
8 weeks
期刊介绍: Clin Exp Vaccine Res, the official English journal of the Korean Vaccine Society, is an international, peer reviewed, and open-access journal. It covers all areas related to vaccines and vaccination. Clin Exp Vaccine Res publishes editorials, review articles, special articles, original articles, case reports, brief communications, and correspondences covering a wide range of clinical and experimental subjects including vaccines and vaccination for human and animals against infectious diseases caused by viruses, bacteria, parasites and tumor. The scope of the journal is to disseminate information that may contribute to elaborate vaccine development and vaccination strategies targeting infectious diseases and tumors in human and animals. Relevant topics range from experimental approaches to (pre)clinical trials for the vaccine research based on, but not limited to, basic laboratory, translational, and (pre)clinical investigations, epidemiology of infectious diseases and progression of all aspects in the health related issues. It is published printed and open accessed online issues (https://ecevr.org) two times per year in 31 January and 31 July. Clin Exp Vaccine Res is linked to many international databases and is made freely available to institutions and individuals worldwide
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