Bellmunt risk score as a survival predictor in patients with metastatic castration-resistant prostate cancer.

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Prostate Pub Date : 2024-09-01 Epub Date: 2024-05-15 DOI:10.1002/pros.24747
Thomas Büttner, Niklas Klümper, Richard Weiten, Philipp Lossin, Stefan Latz, Carolin Jacobs, Manuel Ritter, Stefan Hauser, Jörg Ellinger, Philipp Krausewitz
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Abstract

Background: The prognosis of metastatic castration-resistant prostate cancer (mCRPC) is influenced by numerous individual factors. Despite various proposed prognostic models, the clinical application of these remains limited, probably due to complexity. Our study aimed to evaluate the predictive value of the Bellmunt risk score, which is well-known for urothelial carcinoma and easily assessed, in mCRPC patients.

Methods: The Bellmunt risk score was calculated from three risk factors (Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥1, serum hemoglobin <10 g/dL, presence of liver metastases) in 125 patients who received first-line mCRPC treatment between 2005 and 2023. In addition, a modified score was established (one point each for hemoglobin <10 g/dL and the presence of liver metastases added to the ECOG PS). Associations with overall survival (OS) under first- and second-line therapy were tested using Cox regression analyzes, log-rank tests, concordance index (C-index) and time-dependent receiver operating characteristic.

Results: There is a significant correlation between the level of the Bellmunt risk score and shorter OS (hazard ratio: 3.23, 95% confidence interval: 2.06-5.05; log-rank p < 0.001; C-index: 0.724). The semi-quantitative modified risk score showed even better prognostic discrimination (log-rank p < 0.001, C-index: 0.764). The score and its dynamics were also predictive in the second-line setting (log-rank p < 0.001 and = 0.01; C-index: 0.742 and 0.595).

Conclusions: The Bellmunt risk score is easy to assess and provides useful prognostic information in mCRPC, and can support physicians in their treatment decisions.

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Bellmunt 风险评分作为转移性去势抵抗性前列腺癌患者的生存预测指标。
背景:转移性抗性前列腺癌(mCRPC)的预后受多种个体因素的影响。尽管提出了各种预后模型,但这些模型的临床应用仍然有限,原因可能在于其复杂性。我们的研究旨在评估Bellmunt风险评分对mCRPC患者的预测价值:Bellmunt 风险评分由三个风险因素(东部合作肿瘤学组表现状态(ECOG PS)≥1、血清血红蛋白)计算得出:Bellmunt风险评分的高低与较短的OS之间存在明显的相关性(危险比:3.23,95%置信区间:2.06-5.05;log-rank p 结论:Bellmunt风险评分简单易用,但对OS的影响很大:Bellmunt风险评分易于评估,可为mCRPC提供有用的预后信息,有助于医生做出治疗决定。
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来源期刊
Prostate
Prostate 医学-泌尿学与肾脏学
CiteScore
5.10
自引率
3.60%
发文量
180
审稿时长
1.5 months
期刊介绍: The Prostate is a peer-reviewed journal dedicated to original studies of this organ and the male accessory glands. It serves as an international medium for these studies, presenting comprehensive coverage of clinical, anatomic, embryologic, physiologic, endocrinologic, and biochemical studies.
期刊最新文献
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