{"title":"Design principles as minimal models","authors":"Wei Fang","doi":"10.1016/j.shpsa.2024.03.003","DOIUrl":null,"url":null,"abstract":"<div><p>In this essay I suggest that we view design principles in systems biology as minimal models, for a design principle usually exhibits universal behaviors that are common to a whole range of heterogeneous (living and nonliving) systems with different underlying mechanisms. A well-known design principle in systems biology, <span><em>integral feedback control</em></span>, is discussed, showing that it satisfies all the conditions for a model to be a minimal model. This approach has significant philosophical implications: it not only accounts for how design principles explain, but also helps clarify one dispute over design principles, e.g., whether design principles provide mechanistic explanations or a distinct kind of explanations called <span><em>design explanations</em></span>.</p></div>","PeriodicalId":49467,"journal":{"name":"Studies in History and Philosophy of Science","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Studies in History and Philosophy of Science","FirstCategoryId":"98","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039368124000517","RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HISTORY & PHILOSOPHY OF SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
In this essay I suggest that we view design principles in systems biology as minimal models, for a design principle usually exhibits universal behaviors that are common to a whole range of heterogeneous (living and nonliving) systems with different underlying mechanisms. A well-known design principle in systems biology, integral feedback control, is discussed, showing that it satisfies all the conditions for a model to be a minimal model. This approach has significant philosophical implications: it not only accounts for how design principles explain, but also helps clarify one dispute over design principles, e.g., whether design principles provide mechanistic explanations or a distinct kind of explanations called design explanations.
期刊介绍:
Studies in History and Philosophy of Science is devoted to the integrated study of the history, philosophy and sociology of the sciences. The editors encourage contributions both in the long-established areas of the history of the sciences and the philosophy of the sciences and in the topical areas of historiography of the sciences, the sciences in relation to gender, culture and society and the sciences in relation to arts. The Journal is international in scope and content and publishes papers from a wide range of countries and cultural traditions.