{"title":"Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers","authors":"Xin Chen, Wenying Qiu, Xuqian Ma, Linli Ren, Mingqian Feng, Sheng Hu, Chang Xue, Runzhi Chen","doi":"10.31083/j.fbl2905182","DOIUrl":null,"url":null,"abstract":"Choline participates in three major metabolic pathways: oxidation, phosphorylation, and acetylation. Through oxidation, choline is converted to betaine and contributes to methyl metabolism and epigenetic regulation. Through phosphorylation, choline participates in phospholipid metabolism, and serves as the precursor of phosphocholine, phosphatidylcholine, glycerophosphocholine","PeriodicalId":503756,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":" 2","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioscience-Landmark","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31083/j.fbl2905182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Choline participates in three major metabolic pathways: oxidation, phosphorylation, and acetylation. Through oxidation, choline is converted to betaine and contributes to methyl metabolism and epigenetic regulation. Through phosphorylation, choline participates in phospholipid metabolism, and serves as the precursor of phosphocholine, phosphatidylcholine, glycerophosphocholine
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