Side effects of proton pump inhibitors with long-term use: focus on the urinary system

D. Trukhan, I. Viktorova
{"title":"Side effects of proton pump inhibitors with long-term use: focus on the urinary system","authors":"D. Trukhan, I. Viktorova","doi":"10.33667/2078-5631-2024-5-36-42","DOIUrl":null,"url":null,"abstract":"Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the associations between PPIs and a number of diseases/conditions. We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to January 30, 2024. In this review, we examined the effect of long-term use of PPIs on the urinary system. This review demonstrates possible changes in the urinary system and an increased risk of developing nephrolithiasis, acute interstitial nephritis, acute kidney injury, chronic kidney disease, end-stage renal failure with long-term use of PPIs, which should certainly be taken into account when prescribing them for a long period, especially in patients with comorbid pathology.","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":"76 s323","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical alphabet","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33667/2078-5631-2024-5-36-42","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the associations between PPIs and a number of diseases/conditions. We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to January 30, 2024. In this review, we examined the effect of long-term use of PPIs on the urinary system. This review demonstrates possible changes in the urinary system and an increased risk of developing nephrolithiasis, acute interstitial nephritis, acute kidney injury, chronic kidney disease, end-stage renal failure with long-term use of PPIs, which should certainly be taken into account when prescribing them for a long period, especially in patients with comorbid pathology.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
长期使用质子泵抑制剂的副作用:关注泌尿系统
质子泵抑制剂(PPI)是治疗胃酸相关疾病的最有效药物。近几十年来,PPIs 的使用量成倍增加。长期以来,PPIs 被认为是短期和长期使用都完全安全的药物。然而,现代临床指南指出,在长期大剂量处方 PPIs 时,应考虑到副作用的可能性。近年来,国外发表了多篇综述,探讨了 PPI 与多种疾病/病症之间的关联。我们在 PubMed 和 Scopus 信息数据库中搜索了有关 PPI 使用安全性的出版物,包括截至 2024 年 1 月 30 日的资料来源。在这篇综述中,我们研究了长期服用 PPI 对泌尿系统的影响。本综述表明,长期使用 PPIs 可能会导致泌尿系统发生变化,并增加患肾炎、急性间质性肾炎、急性肾损伤、慢性肾病、终末期肾衰竭的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Kidney autotransplantation with renal arteries injury in a patient with Takayasu arteritis Osteopoikilia in the practice of a rheumatologist Современные маркеры диагностики сочетания анкилозирующего спондилита и воспалительных заболеваний кишечника Onset of Rheumatoid Arthritis with eye manifestations (clinical case report) Peculiarities of laboratory parameters dynamics during helicobacter pylori eradication in patients with rheumatoid arthritis
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1